Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism
المؤلفون المشاركون
Kuo, Yueh-Hsiung
Liao, Jiunn-Wang
Gokila Vani, M.
Wang, Sheng-Yang
Chien, Shih-Chang
Kumar, K. J. Senthil
Mau, Jeng-Leun
Chiang, Shen-Shih
Lin, Chin-Chung
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-11
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
In this study, we investigated the cytoprotective effects of antcin C, a steroid-like compound isolated from Antrodia cinnamaomea against AAPH-induced oxidative stress and apoptosis in human hepatic HepG2 cells.
Pretreatment with antcin C significantly protects hepatic cells from AAPH-induced cell death through the inhibition of ROS generation.
Furthermore, AAPH-induced lipid peroxidation, ALT/AST secretion and GSH depletion was significantly inhibited by antcin C.
The antioxidant potential of antcin C was correlated with induction of antioxidant genes including, HO-1, NQO-1, γ-GCLC, and SOD via transcriptional activation of Nrf2.
The Nrf2 activation by antcin C is mediated by JNK1/2 and PI3K activation, whereas pharmacologic inhibition of JNK1/2 and PI3K abolished antcin C-induced Nrf2 activity.
In addition, AAPH-induced apoptosis was significantly inhibited by antcin C through the down-regulation of pro-apoptotic factors including, Bax, cytochrome c, capase 9, -4, -12, -3, and PARP.
In vivo studies also show that antcin C significantly protected mice liver from AAPH-induced hepatic injury as evidenced by reduction in hepatic enzymes in circulation.
Further, immunocytochemistry analyses showed that antcin C significantly increased HO-1 and Nrf2 expression in mice liver tissues.
These results strongly suggest that antcin C could protect liver cells from oxidative stress and cell death via Nrf2/ARE activation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gokila Vani, M.& Kumar, K. J. Senthil& Liao, Jiunn-Wang& Chien, Shih-Chang& Mau, Jeng-Leun& Chiang, Shen-Shih…[et al.]. 2013. Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-461288
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gokila Vani, M.…[et al.]. Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-461288
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gokila Vani, M.& Kumar, K. J. Senthil& Liao, Jiunn-Wang& Chien, Shih-Chang& Mau, Jeng-Leun& Chiang, Shen-Shih…[et al.]. Antcin C from Antrodia cinnamomea Protects Liver Cells Against Free Radical-Induced Oxidative Stress and Apoptosis In Vitro and In Vivo through Nrf2-Dependent Mechanism. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-461288
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461288
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر