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Interaction of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol : Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects
المؤلفون المشاركون
Mizogami, Maki
Tsuchiya, Hironori
المصدر
Anesthesiology Research and Practice
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-23
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Despite a long history in medical and dental application, the molecular mechanism and precise site of action are still arguable for local anesthetics.
Their effects are considered to be induced by acting on functional proteins, on membrane lipids, or on both.
Local anesthetics primarily interact with sodium channels embedded in cell membranes to reduce the excitability of nerve cells and cardiomyocytes or produce a malfunction of the cardiovascular system.
However, the membrane protein-interacting theory cannot explain all of the pharmacological and toxicological features of local anesthetics.
The administered drug molecules must diffuse through the lipid barriers of nerve sheaths and penetrate into or across the lipid bilayers of cell membranes to reach the acting site on transmembrane proteins.
Amphiphilic local anesthetics interact hydrophobically and electrostatically with lipid bilayers and modify their physicochemical property, with the direct inhibition of membrane functions, and with the resultant alteration of the membrane lipid environments surrounding transmembrane proteins and the subsequent protein conformational change, leading to the inhibition of channel functions.
We review recent studies on the interaction of local anesthetics with biomembranes consisting of phospholipids and cholesterol.
Understanding the membrane interactivity of local anesthetics would provide novel insights into their anesthetic and cardiotoxic effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsuchiya, Hironori& Mizogami, Maki. 2013. Interaction of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol : Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects. Anesthesiology Research and Practice،Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-461389
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsuchiya, Hironori& Mizogami, Maki. Interaction of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol : Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects. Anesthesiology Research and Practice No. 2013 (2013), pp.1-18.
https://search.emarefa.net/detail/BIM-461389
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsuchiya, Hironori& Mizogami, Maki. Interaction of Local Anesthetics with Biomembranes Consisting of Phospholipids and Cholesterol : Mechanistic and Clinical Implications for Anesthetic and Cardiotoxic Effects. Anesthesiology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-18.
https://search.emarefa.net/detail/BIM-461389
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461389
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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