Serum Endostatin Concentrations Are Higher in Men with Symptoms of Intermittent Claudication
المؤلفون المشاركون
Clancy, Paula
Hankey, Graeme J.
Golledge, Jonathan
Norman, Paul E.
Yeap, Bu B.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-30
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Objectives.
A cleavage fragment of collagen XVIII, endostatin, is released into the circulation and has been demonstrated to have antiangiogenic effects in animal models.
We hypothesized that circulating endostatin would be increased in patients with symptoms of lower limb peripheral artery disease.
Design.
Cross-sectional study.
Participants.
Community dwelling older men.
Measurements.
Intermittent claudication was defined using the Edinburgh Claudication Questionnaire (ECQ).
Serum endostatin was measured by a commercial ELISA.
The association of serum endostatin with intermittent claudication was examined using logistic regression adjusting for age, diabetes, hypertension, dyslipidemia, coronary heart disease, and stroke.
Results.
Serum endostatin was measured in 1114 men who completed the ECQ.
106 men had intermittent claudication, 291 had atypical pain, and 717 had no lower limb pain.
Mean (±standard deviation) serum endostatin concentrations (ng/mL) were 145.22 ± 106.93 for men with intermittent claudication, 129.11 ± 79.80 for men with atypical pain, and 116.34 ± 66.57 for men with no lower limb pain; P<0.001.
A 70 ng/mL increase in endostatin was associated with a 1.17-fold rise in the adjusted odds of having intermittent claudication (OR 1.17, 95% confidence interval 1.00–1.37, and P=0.050).
Conclusions.
Serum endostatin is raised in older men who have symptoms of intermittent claudication.
The role of endostatin in the genesis and outcome of peripheral artery disease requires further investigation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Golledge, Jonathan& Clancy, Paula& Hankey, Graeme J.& Yeap, Bu B.& Norman, Paul E.. 2014. Serum Endostatin Concentrations Are Higher in Men with Symptoms of Intermittent Claudication. Disease Markers،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-461496
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Golledge, Jonathan…[et al.]. Serum Endostatin Concentrations Are Higher in Men with Symptoms of Intermittent Claudication. Disease Markers No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-461496
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Golledge, Jonathan& Clancy, Paula& Hankey, Graeme J.& Yeap, Bu B.& Norman, Paul E.. Serum Endostatin Concentrations Are Higher in Men with Symptoms of Intermittent Claudication. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-461496
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461496
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر