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High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma
المؤلفون المشاركون
Zhao, Mengyang
Wang, Lijing
Fang, Weiyi
Wu, Qiangyun
Fu, Qiaofen
Hua, Shengni
Jiang, Qingping
Guo, Suiqun
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-02-17
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Aims.
This study examined the correlation between high nuclear expression of hepatoma-derived growth factor (HDGF) and clinicopathologic data in endometrial carcinoma (EC), including patient survival.
Methods.
One hundred and twenty-two endometrial carcinoma (EC) patients from 2002 to 2008 were reviewed in the study.
HDGF expression in tumor tissues was examined using immunohistochemistry (IHC), and its association with clinicopathological parameters was evaluated.
Tumors with 80% or more nuclei staining were regarded as high expression and tumors with less than 80% nuclei staining considered as low expression.
Results and Conclusions.
Immunohistochemical analysis revealed that HDGF was expressed in both the nucleus and cytoplasm.
High nuclear expression of HDGF was positively correlated with FIGO stage (P=0.032), but not associated with other clinical features, such as histological grading or lymph node status.
Patients with high expression of HDGF had poorer overall survival rates than those with low expression of HDGF (P=0.001).
However, multivariate analyses showed that high nuclear expression of HDGF protein was not an independent predictor of prognosis for EC patients (P=0.111).
Our results suggest that high nuclear expression of HDGF is a potential unfavorable factor for the progression and prognosis of EC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Lijing& Jiang, Qingping& Hua, Shengni& Zhao, Mengyang& Wu, Qiangyun& Fu, Qiaofen…[et al.]. 2014. High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461549
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Lijing…[et al.]. High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-461549
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Lijing& Jiang, Qingping& Hua, Shengni& Zhao, Mengyang& Wu, Qiangyun& Fu, Qiaofen…[et al.]. High Nuclear Expression of HDGF Correlates with Disease Progression and Poor Prognosis in Human Endometrial Carcinoma. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-461549
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461549
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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