Significant Differences in Markers of Oxidant Injury between Idiopathic and Bronchopulmonary-Dysplasia-Associated Pulmonary Hypertension in Children
المؤلفون المشاركون
Liske, Michael
Flack, English
Moore, Donald
Vera, Kimberly B.
Summar, Marshall
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-05
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
While oxidant stress is elevated in adult forms of pulmonary hypertension (PH), levels of oxidant stress in pediatric PH are unknown.
The objective of this study is to measure F2-isoprostanes, a marker of oxidant stress, in children with idiopathic pulmonary hypertension (IPH) and PH due to bronchopulmonary dysplasia (BPD).
We hypothesized that F2-isoprostanes in pediatric IPH and PH associated with BPD will be higher than in controls.
Plasma F2-isoprostanes were measured in pediatric PH patients during clinically indicated cardiac catheterization and compared with controls.
F2-Isoprostane levels were compared between IPH, PH due to BD, and controls.
Five patients with IPH, 12 with PH due to BPD, and 20 control subjects were studied.
Patients with IPH had statistically higher isoprostanes than controls 62 pg/mL (37–210) versus 20 pg/mL (16–27), P<0.01).
The patients with PH and BPD had significantly lower isoprostanes than controls 15 pg/mL (8–17) versus 20 pg/ml (16–27), P<0.02.
F2-isoprostanes are elevated in children with IPH compared to both controls and patients with PH secondary to BPD.
Furthermore, F2-isoprostanes in PH secondary to BPD are lower than control levels.
These findings suggest that IPH and PH secondary to BPD have distinct mechanisms of disease pathogenesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Vera, Kimberly B.& Moore, Donald& Flack, English& Liske, Michael& Summar, Marshall. 2012. Significant Differences in Markers of Oxidant Injury between Idiopathic and Bronchopulmonary-Dysplasia-Associated Pulmonary Hypertension in Children. Pulmonary Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-461602
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Vera, Kimberly B.…[et al.]. Significant Differences in Markers of Oxidant Injury between Idiopathic and Bronchopulmonary-Dysplasia-Associated Pulmonary Hypertension in Children. Pulmonary Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-461602
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Vera, Kimberly B.& Moore, Donald& Flack, English& Liske, Michael& Summar, Marshall. Significant Differences in Markers of Oxidant Injury between Idiopathic and Bronchopulmonary-Dysplasia-Associated Pulmonary Hypertension in Children. Pulmonary Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-461602
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461602
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر