De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients : A Place for Interaction?
المؤلفون المشاركون
Morales-Buenrostro, Luis E.
Crispín, José C.
Rodríguez-Romo, Roxana
Gómez-Martín, Diana
Carrasco, Gabriel
Vargas-Rojas, Maria Inés
Alberu, Josefina
Ofelia Uribe-Uribe, Norma
Alcocer-Varela, Jorge
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-08-23
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
The aim of this study was to determine whether the abundance of regulatory T cells (Tregs) (CD4+CD25high) affects the de novo development of anti-HLA donor-specific antibodies (DSAs) in kidney transplant recipients (KTRs).
Methods.
Unsensitized (PRA ≤ 10%, no DSA) adult primary KTRs who received a living (83%) or deceased (17%) KT in our Institution during 2004/2005 were included.
DSA testing was performed monthly, and Tregs were quantified by flow cytometry every 3 months, during the 1st year after KT.
All patients received triple drug immunosuppressive therapy (CNI + MMF or AZA + PDN); 83% received anti-CD25.
Results.
53 KTRs were included; 32% developed DSA during the 1st year after KT.
Significantly lower 7-year graft survival was observed in those who developed DSA.
No difference was observed in Treg numbers up to 9 months after KT, between DSA positive and negative.
However, at 12 months after KT, DSA-negative patients had significantly higher numbers of Treg.
Conclusions.
Early development of DSA was not associated to variations in Treg abundance.
The differences in Treg numbers observed at the late time point may reflect better immune acceptance of the graft and may be associated to long-term effects.
Additional inhibitory mechanisms participating earlier in DSA development after KT deserve to be sought.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alberu, Josefina& Vargas-Rojas, Maria Inés& Morales-Buenrostro, Luis E.& Crispín, José C.& Rodríguez-Romo, Roxana& Ofelia Uribe-Uribe, Norma…[et al.]. 2012. De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients : A Place for Interaction?. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461697
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alberu, Josefina…[et al.]. De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients : A Place for Interaction?. Journal of Transplantation No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-461697
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alberu, Josefina& Vargas-Rojas, Maria Inés& Morales-Buenrostro, Luis E.& Crispín, José C.& Rodríguez-Romo, Roxana& Ofelia Uribe-Uribe, Norma…[et al.]. De Novo Donor-Specific HLA Antibody Development and Peripheral CD4+CD25high Cells in Kidney Transplant Recipients : A Place for Interaction?. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-461697
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461697
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر