Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice
المؤلفون المشاركون
Kawahashi-Tokuhisa, Miho
Yui, Katsuyuki
Kondo, Naoyuki
Tanabe, Kenichi
Yamaguchi, Yoshitake
Ushiroda, Chihiro
Hashiguchi, Michiru
Oku, Tsuneyuki
Miyakoda, Mana
Nakamura, Sadako
المصدر
Gastroenterology Research and Practice
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-02
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
We hypothesized that daily intake of nondigestible saccharides delays senescence onset through the improvement of intestinal microflora.
Here, we raised senescence accelerated mice prone 8 (SAMP8) on the AIN93 diet (CONT), with sucrose being substituted for 5% of fructooligosaccharide (FOS) or 5% of glucomannan (GM), 15 mice per group.
Ten SAMR1 were raised as reference of normal aging with control diet.
Grading of senescence was conducted using the method developed by Hosokawa, and body weight, dietary intake, and drinking water intake were measured on alternate days.
Following 38 weeks of these diets we evaluated learning and memory abilities using a passive avoidance apparatus and investigated effects on the intestinal microflora, measured oxidative stress markers, and inflammatory cytokines.
Continuous intake of FOS and GM significantly enhanced learning and memory ability and decelerated senescence development when compared with the CONT group.
Bifidobacterium levels were significantly increased in FOS and GM-fed mice.
Urinary 8OHdG, 15-isoprostane, serum TNF-α, and IL-6 were also lower in FOS-fed mice, while IL-10 in FOS and GM groups was higher than in CONT group.
These findings suggest that daily intake of nondigestible saccharides delays the onset of senescence via improvement of intestinal microflora.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nakamura, Sadako& Kondo, Naoyuki& Yamaguchi, Yoshitake& Hashiguchi, Michiru& Tanabe, Kenichi& Ushiroda, Chihiro…[et al.]. 2014. Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice. Gastroenterology Research and Practice،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-461768
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nakamura, Sadako…[et al.]. Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice. Gastroenterology Research and Practice No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-461768
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nakamura, Sadako& Kondo, Naoyuki& Yamaguchi, Yoshitake& Hashiguchi, Michiru& Tanabe, Kenichi& Ushiroda, Chihiro…[et al.]. Daily Feeding of Fructooligosaccharide or Glucomannan Delays Onset of Senescence in SAMP8 Mice. Gastroenterology Research and Practice. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-461768
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461768
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر