High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas
المؤلفون المشاركون
Lukesova, Eva
Klozar, J.
Koslabova, E.
Salakova, M.
Eckschlager, T.
Boucek, Jan
Rihova, B.
Rotnaglova, E.
Tachezy, R.
Prochazka, B.
Grega, M.
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-23
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Background.
Human papillomaviruses (HPVs) have been proved as one of the etiological factors of oropharyngeal squamous cell carcinoma (OPSCC).
Patients with tumors of viral etiology have a lower recurrence rate and better prognosis.
OPSCC is linked to an alteration in the immune system.
Only a limited number of studies have correlated both the immunological parameters and HPV status with patient prognosis.
The aim of this study was to determine whether HPV infection and the immunological status influence patient prognosis individually or in concurrence.
Material and Methods.
Sixty patients with oral and oropharyngeal carcinomas were enrolled.
They were divided into HPV-positive and HPV-negative groups based on the expression of HPV 16 E6 mRNA.
Basic lymphocyte subpopulations were determined in the peripheral blood by means of flow cytometry.
Results.
Significantly better disease-specific survival (DSS) was observed in patients with HPV-positive tumors.
Nodal status, tumor grade, recurrence, and CD8+/Tregs ratio were identified as factors influencing DSS.
A higher level of Tregs and a lower ratio of CD8/Tregs influenced overall survival (OS) independently of HPV status and age.
Patients with HPV-positive tumors and high levels of Tregs survived significantly better than patients from the other groups.
Conclusion.
Better survival is associated with HPV positivity and elevated Tregs levels.
Our data suggest that HPV infection and Tregs do not influence patient prognosis in concurrence.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lukesova, Eva& Boucek, Jan& Rotnaglova, E.& Salakova, M.& Koslabova, E.& Grega, M.…[et al.]. 2014. High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-461829
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lukesova, Eva…[et al.]. High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-461829
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lukesova, Eva& Boucek, Jan& Rotnaglova, E.& Salakova, M.& Koslabova, E.& Grega, M.…[et al.]. High Level of Tregs Is a Positive Prognostic Marker in Patients with HPV-Positive Oral and Oropharyngeal Squamous Cell Carcinomas. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-461829
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461829
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر