Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity
المؤلفون المشاركون
Lage, Paula Sousa
Costa, Lourena Emanuele
Chávez Fumagalli, Miguel Angel
Leite, João Paulo Viana
Pagliara Lage, Daniela
Valadares, Diogo Garcia
Coelho, Eduardo Antonio Ferraz
Tavares, Carlos Alberto Pereira
de Andrade, Pedro Henrique Rocha
Lopes, Amanda de Santana
Duarte, Mariana Costa
Martins, Vivian Tamietti
Ribeiro, Tatiana Gomes
Filho, José Dias de Souza
Pádua, Rodrigo Maia de
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-30
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
The development of new and cost-effective alternative therapeutic strategies to treat leishmaniasis has become a high priority.
In the present study, the antileishmanial activity of Strychnos pseudoquina St.
Hil.
was investigated and pure compounds that presented this biological effect were isolated.
An ethyl acetate extract was prepared, and it proved to be effective against Leishmania amazonensis.
A bioactivity-guided fractionation was performed, and two flavonoids were identified, quercetin 3-O-methyl ether and strychnobiflavone, which presented an effective antileishmanial activity against L.
amazonensis, and studies were extended to establish their minimum inhibitory concentrations (IC50), their leishmanicidal effects on the intra-macrophage Leishmania stage, as well as their cytotoxic effects on murine macrophages (CC50), and in O+ human red blood cells.
The data presented in this study showed the potential of an ethyl acetate extract of S.
pseudoquina, as well as two flavonoids purified from it, which can be used as a therapeutic alternative on its own, or in association with other drugs, to treat disease evoked by L.
amazonensis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lage, Paula Sousa& de Andrade, Pedro Henrique Rocha& Lopes, Amanda de Santana& Chávez Fumagalli, Miguel Angel& Valadares, Diogo Garcia& Duarte, Mariana Costa…[et al.]. 2013. Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-461861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lage, Paula Sousa…[et al.]. Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-9.
https://search.emarefa.net/detail/BIM-461861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lage, Paula Sousa& de Andrade, Pedro Henrique Rocha& Lopes, Amanda de Santana& Chávez Fumagalli, Miguel Angel& Valadares, Diogo Garcia& Duarte, Mariana Costa…[et al.]. Strychnos pseudoquina and Its Purified Compounds Present an Effective In Vitro Antileishmanial Activity. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-9.
https://search.emarefa.net/detail/BIM-461861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر