Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein
المؤلفون المشاركون
Yokoyama, Shoko
Ohtsuka, Isao
Sadakane, Yutaka
Kawahara, Masahiro
Kato-Negishi, Midori
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-04-12
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Oligomerization, conformational changes, and the consequent neurodegeneration of Alzheimer's β-amyloid protein (AβP) play crucial roles in the pathogenesis of Alzheimer's disease (AD).
Mounting evidence suggests that oligomeric AβPs cause the disruption of calcium homeostasis, eventually leading to neuronal death.
We have demonstrated that oligomeric AβPs directly incorporate into neuronal membranes, form cation-sensitive ion channels (“amyloid channels”), and cause the disruption of calcium homeostasis via the amyloid channels.
Other disease-related amyloidogenic proteins, such as prion protein in prion diseases or α-synuclein in dementia with Lewy bodies, exhibit similarities in the incorporation into membranes and the formation of calcium-permeable channels.
Here, based on our experimental results and those of numerous other studies, we review the current understanding of the direct binding of AβP into membrane surfaces and the formation of calcium-permeable channels.
The implication of composition of membrane lipids and the possible development of new drugs by influencing membrane properties and attenuating amyloid channels for the treatment and prevention of AD is also discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kawahara, Masahiro& Ohtsuka, Isao& Yokoyama, Shoko& Kato-Negishi, Midori& Sadakane, Yutaka. 2011. Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-461873
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kawahara, Masahiro…[et al.]. Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-17.
https://search.emarefa.net/detail/BIM-461873
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kawahara, Masahiro& Ohtsuka, Isao& Yokoyama, Shoko& Kato-Negishi, Midori& Sadakane, Yutaka. Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-17.
https://search.emarefa.net/detail/BIM-461873
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461873
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر