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Vitamin D and Serum Cytokines in a Randomized Clinical Trial
المؤلفون المشاركون
Yusupov, Eleanor
Yeh, James K.
Mikhail, Mageda
Pollack, Simcha
Aloia, John F.
Li-Ng, Melissa
المصدر
International Journal of Endocrinology
العدد
المجلد 2010، العدد 2010 (31 ديسمبر/كانون الأول 2010)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2010-08-12
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background.
The role of vitamin D in the body's ability to fight influenza and URI's may be dependent on regulation of specific cytokines that participate in the host inflammatory response.
The aim of this study was to test the hypothesis that vitamin D can influence intracellular signaling to regulate the production of cytokines.
Subjects and Methods.
This study was a 3-month prospective placebo-controlled trial of vitamin D3 supplementation in ambulatory adults [Li-Ng et al., 2009].
162 volunteers were randomized to receive either 50 μg/d (2000 IU) of vitamin D3 or matching placebo.
25(OH)D and the levels of 10 different cytokines (IL-2, 4, 5, 6, 8, 10, 13, GM-CSF, IFN-γ, TNF-α) were measured in the serum of participants at baseline and the final visit.
There were 6 drop-outs from the active vitamin D group and 8 from the placebo group.
Results.
In the active vitamin D group, we found a significant median percent decline in levels of GM-CSF (−62.9%, P<.0001), IFN-γ (−38.9%, P<.0001), IL-4 (−50.8%, P=.001), IL-8 (−48.4%, P<.0001), and IL-10 (−70.4%, P<.0001).
In the placebo group, there were significant declines for GM-CSF (−53.2%, P=.0007) and IFN-γ (−34.4%, P=.0011).
For each cytokine, there was no significant difference in the rate of decline between the two groups.
25(OH)D levels increased in the active vitamin D group from a mean of 64.3±25.4 nmol/L to 88.5±23.2 nmol/L.
Conclusions.
The present study did not show that vitamin D3 supplementation changed circulating cytokine levels among healthy adults.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yusupov, Eleanor& Li-Ng, Melissa& Pollack, Simcha& Yeh, James K.& Mikhail, Mageda& Aloia, John F.. 2010. Vitamin D and Serum Cytokines in a Randomized Clinical Trial. International Journal of Endocrinology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-461915
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yusupov, Eleanor…[et al.]. Vitamin D and Serum Cytokines in a Randomized Clinical Trial. International Journal of Endocrinology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-461915
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yusupov, Eleanor& Li-Ng, Melissa& Pollack, Simcha& Yeh, James K.& Mikhail, Mageda& Aloia, John F.. Vitamin D and Serum Cytokines in a Randomized Clinical Trial. International Journal of Endocrinology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-461915
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461915
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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