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Different Effects of Angiotensin Converting Enzyme Inhibitors on Endothelin-1 and Nitric Oxide Balance in Human Vascular Endothelial Cells : Evidence of an Oxidant-Sensitive Pathway
المؤلفون المشاركون
Desideri, Giovambattista
Grassi, Davide
Ferri, Claudio
Tiberti, Sergio
Necozione, Stefano
Evangelista, Stefano
Bocale, Raffaella
Di Orio, Ferdinando
Croce, Giuseppe
المصدر
العدد
المجلد 2008، العدد 2008 (31 ديسمبر/كانون الأول 2008)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2008-12-01
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Angiotensin converting enzyme inhibitors (ACE-I) are able to reduce the formation of the potent vasoconstrictor endothelin-1 and increase nitric oxide bioavailability in human vascular endothelial cells (HUVECs).
We tested the effects of two sulfhydryl containing ACE-I, zofenoprilat, and captopril, and two nonsulfhydryl containing ACE-I, enalaprilat and lisinopril, on endothelin-1/nitric oxide balance and oxidative stress in HUVECs.
All the four tested ACE-I reduced endothelin-1 secretion and increased nitric oxide metabolite production by HUVECs.
However, zofenoprilat (−42% after 8 hours of incubation) was more effective (P<.05) than enalaprilat (−25%), lisinopril (−21%), and captopril (−30%) in reducing endothelin-1 secretion.
Similarly, zofenoprilat (+110% after 8 hours of incubation) was more effective (P<.05) than enalaprilat (+64%), lisinopril (+63%), and captopril (+65%) in increasing nitric oxide metabolite production.
The effect of ACE-I on endothelin-1 and nitric oxide metabolite production is mediated by the activation of bradykinin B2 receptor being counteracted, at least in part, by a specific antagonist.
Zofenoprilat and, to a lesser extent, captopril also reduced oxidative stress in HUVECs.
In conclusion, among the four tested ACE-I, zofenoprilat was more effective in improving endothelin-1/nitric oxide balance in HUVECs likely because of its greater antioxidant properties.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Desideri, Giovambattista& Grassi, Davide& Croce, Giuseppe& Bocale, Raffaella& Tiberti, Sergio& Evangelista, Stefano…[et al.]. 2008. Different Effects of Angiotensin Converting Enzyme Inhibitors on Endothelin-1 and Nitric Oxide Balance in Human Vascular Endothelial Cells : Evidence of an Oxidant-Sensitive Pathway. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-461918
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Desideri, Giovambattista…[et al.]. Different Effects of Angiotensin Converting Enzyme Inhibitors on Endothelin-1 and Nitric Oxide Balance in Human Vascular Endothelial Cells : Evidence of an Oxidant-Sensitive Pathway. Mediators of Inflammation No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-461918
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Desideri, Giovambattista& Grassi, Davide& Croce, Giuseppe& Bocale, Raffaella& Tiberti, Sergio& Evangelista, Stefano…[et al.]. Different Effects of Angiotensin Converting Enzyme Inhibitors on Endothelin-1 and Nitric Oxide Balance in Human Vascular Endothelial Cells : Evidence of an Oxidant-Sensitive Pathway. Mediators of Inflammation. 2008. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-461918
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-461918
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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