Preliminary Clinical Experience of trans-1-Amino-3-(18)‎F-fluorocyclobutanecarboxylic Acid (anti-(18)‎F-FACBC)‎ PETCT Imaging in Prostate Cancer Patients

الملخص EN

Background.

In this retrospective analysis we assessed the role of [18F]-FACBC-PET/CT in the prostatic cancer staging.

Procedure.

30 first [18F]-FACBC-PET/CT images of 26 patients (68.1 ± 5.8 years) were analyzed.

PET/CT findings were compared with PSA concentrations, with PSA doubling times (PDT), and with correlative imaging.

Results.

On 16 [18F]-FACBC (53.3%) scans, 58 metabolically active lesions were found.

12 (20.7%) lesions corresponding to the local relapse were found in prostate/prostate bed and seminal vesicles, 9 (15.5%) lesions were located in regional lymph nodes, 10 (17.2%) were located in distal lymph nodes, and 26 (44.8%) metabolically active lesions were found in the skeleton.

In one case, focal uptake was found in the brain, confirmed further on MRI as meningioma.

The mean S-PSA level in patients with positive [18F]-FACBC findings was 9.5 ± 16.9 μg/L (0.54–69 μg/L) and in patients with negative [18F]-FACBC findings was 1.96 ± 1.87 μg/L (0.11–5.9 μg/L), but the difference was not statistically significant.

However, the PSA doubling time (PDT) in patients with positive findings was significantly shorter than PDT in patients with negative findings: 3.25 ± 2.09 months (0.3–6 months) versus 31.2 ± 22.02 months (8–84 months), P<0.0001.

There was a strong positive correlation between PSA value and number of metabolically active lesions (R=0.74) and a negative correlation between PDT and number of metabolically active lesions (R=-0.56).

There was a weak negative correlation between PDT and SUVmax (R=-0.30).

Conclusion.

According to our preliminary clinical experience, [18F]-FACBC-PET may play a role in in vivo restaging of an active prostate cancer, especially in patients with a short S-PSA doubling time.