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Evaluation of RANKLOPG Serum Concentration Ratio as a New Biomarker for Coronary Artery Calcification : A Pilot Study
المؤلفون المشاركون
Ramezani, Mohammad
Shahsavand, Shabnam
Ghadirzadeh, Samira
Nazemi, Saeed
Shamsara, Jamal
Mohammadpour, Amir Hooshang
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-4، 4ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-28
دولة النشر
مصر
عدد الصفحات
4
التخصصات الرئيسية
الملخص EN
Objective.
There is a strong need for biomarkers to identify patients at risk for future cardiovascular events related with progressive atherosclerotic disease.
Osteoprotegerin (OPG) protects the skeleton from excessive bone resorption by binding to receptor activator of nuclear factor-κB ligand (RANKL) and preventing it from binding to its receptor, receptor activator of nuclear factor-κB.
However, conflicting results have been obtained about association of serum level of OPG or RANKL with coronary artery disease (CAD).
Based on their role in inflammation and matrix degradation and the fact that atherosclerotic plaque formation is an inflammatory process, we hypothesized that RANKL : OPG ratio could be a better biomarker for CAD.
Methods.
In this cross-sectional study, the correlation between RANKL : OPG ratio serum concentration and coronary artery calcification (CAC) in 50 patients with ischemic coronary disease has been investigated.
We used ELISA method for measuring RANKL and OPG serum concentrations.
Results.
There was a significant correlation between RANKL : OPG serum concentration ratio and CAC in our study population (P=0.01).
Conclusion.
Our results suggested that RANKL : OPG ratio concentration has a potential of being used as a marker for coronary artery disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Mohammadpour, Amir Hooshang& Shamsara, Jamal& Nazemi, Saeed& Ghadirzadeh, Samira& Shahsavand, Shabnam& Ramezani, Mohammad. 2012. Evaluation of RANKLOPG Serum Concentration Ratio as a New Biomarker for Coronary Artery Calcification : A Pilot Study. Thrombosis،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-462036
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Mohammadpour, Amir Hooshang…[et al.]. Evaluation of RANKLOPG Serum Concentration Ratio as a New Biomarker for Coronary Artery Calcification : A Pilot Study. Thrombosis No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-462036
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Mohammadpour, Amir Hooshang& Shamsara, Jamal& Nazemi, Saeed& Ghadirzadeh, Samira& Shahsavand, Shabnam& Ramezani, Mohammad. Evaluation of RANKLOPG Serum Concentration Ratio as a New Biomarker for Coronary Artery Calcification : A Pilot Study. Thrombosis. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-462036
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462036
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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