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Experimental Chemotherapy for Chagas Disease : A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones
المؤلفون المشاركون
Batista, Wanderson
Oliveira, Gabriel M.
Soeiro, Maria de Nazaré C.
de Castro, Solange Lisboa
Batista, Denise G. J.
Silva, Cristiane F.
de Souza, Elen M.
Menna-Barreto, Rubem F. S.
Batista, Marcos M.
Silva, Patricia B.
Daliry, Anissa
Salomão, Kelly
المصدر
Molecular Biology International
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-06-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Chagas disease (CD), caused by Trypanosoma cruzi, affects approximately eight million individuals in Latin America and is emerging in nonendemic areas due to the globalisation of immigration and nonvectorial transmission routes.
Although CD represents an important public health problem, resulting in high morbidity and considerable mortality rates, few investments have been allocated towards developing novel anti-T.
cruzi agents.
The available therapy for CD is based on two nitro derivatives (benznidazole (Bz) and nifurtimox (Nf)) developed more than four decades ago.
Both are far from ideal due to substantial secondary side effects, limited efficacy against different parasite isolates, long-term therapy, and their well-known poor activity in the late chronic phase.
These drawbacks justify the urgent need to identify better drugs to treat chagasic patients.
Although several classes of natural and synthetic compounds have been reported to act in vitro and in vivo on T.
cruzi, since the introduction of Bz and Nf, only a few drugs, such as allopurinol and a few sterol inhibitors, have moved to clinical trials.
This reflects, at least in part, the absence of well-established universal protocols to screen and compare drug activity.
In addition, a large number of in vitro studies have been conducted using only epimastigotes and trypomastigotes instead of evaluating compounds' activities against intracellular amastigotes, which are the reproductive forms in the vertebrate host and are thus an important determinant in the selection and identification of effective compounds for further in vivo analysis.
In addition, due to pharmacokinetics and absorption, distribution, metabolism, and excretion characteristics, several compounds that were promising in vitro have not been as effective as Nf or Bz in animal models of T.
cruzi infection.
In the last two decades, our team has collaborated with different medicinal chemistry groups to develop preclinical studies for CD and investigate the in vitro and in vivo efficacy, toxicity, selectivity, and parasite targets of different classes of natural and synthetic compounds.
Some of these results will be briefly presented, focusing primarily on diamidines and related compounds and naphthoquinone derivatives that showed the most promising efficacy against T.
cruzi.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
de Castro, Solange Lisboa& Batista, Denise G. J.& Batista, Marcos M.& Batista, Wanderson& Daliry, Anissa& de Souza, Elen M.…[et al.]. 2011. Experimental Chemotherapy for Chagas Disease : A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones. Molecular Biology International،Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-462101
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
de Castro, Solange Lisboa…[et al.]. Experimental Chemotherapy for Chagas Disease : A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones. Molecular Biology International No. 2011 (2011), pp.1-13.
https://search.emarefa.net/detail/BIM-462101
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
de Castro, Solange Lisboa& Batista, Denise G. J.& Batista, Marcos M.& Batista, Wanderson& Daliry, Anissa& de Souza, Elen M.…[et al.]. Experimental Chemotherapy for Chagas Disease : A Morphological, Biochemical, and Proteomic Overview of Potential Trypanosoma cruzi Targets of Amidines Derivatives and Naphthoquinones. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-13.
https://search.emarefa.net/detail/BIM-462101
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462101
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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