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The Effects of Intravenous Fosaprepitant and Ondansetron for the Prevention of Postoperative Nausea and Vomiting in Neurosurgery Patients : A Prospective, Randomized, Double-Blinded Study
المؤلفون المشاركون
Hamaguchi, Eisuke
Kakuta, Nami
Tanaka, Katsuya
Kume, Katsuyoshi
Tsutsumi, Rie
Tsutsumi, Yasuo M.
Soga, Tomohiro
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-23
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The incidence of postoperative nausea and vomiting (PONV) is 30–50% after surgery.
PONV occurs frequently, especially after craniotomy.
In this study, we investigated the preventive effects on PONV in a randomized study by comparing patients who had been administered fosaprepitant, a neurokinin-1 (NK1) receptor antagonist, or ondansetron intravenously.
Sixty-four patients undergoing craniotomy were randomly allocated to receive fosaprepitant 150 mg i.v.
(NK1 group, n = 32) or ondansetron 4 mg i.v.
(ONS group, n = 32) before anesthesia.
The incidence of vomiting was significantly less in the NK1 group, where 2 of 32 (6%) patients experienced vomiting compared to 16 of 32 (50%) patients in the ONS group during the first 24 and 48 hours following surgery.
Additionally, the incidence of complete response (no vomiting and no rescue antiemetic use) was significantly higher in the NK1 group than in the ONS group, and was 66% versus 41%, respectively, during the first 24 hours, and 63% versus 38%, respectively, during the first 48 hours.
In patients undergoing craniotomy, fosaprepitant is more effective than ondansetron in increasing the rate of complete response and decreasing the incidence of vomiting at 24 and 48 hours postoperatively.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tsutsumi, Yasuo M.& Kakuta, Nami& Soga, Tomohiro& Kume, Katsuyoshi& Hamaguchi, Eisuke& Tsutsumi, Rie…[et al.]. 2014. The Effects of Intravenous Fosaprepitant and Ondansetron for the Prevention of Postoperative Nausea and Vomiting in Neurosurgery Patients : A Prospective, Randomized, Double-Blinded Study. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-462109
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tsutsumi, Yasuo M.…[et al.]. The Effects of Intravenous Fosaprepitant and Ondansetron for the Prevention of Postoperative Nausea and Vomiting in Neurosurgery Patients : A Prospective, Randomized, Double-Blinded Study. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-462109
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tsutsumi, Yasuo M.& Kakuta, Nami& Soga, Tomohiro& Kume, Katsuyoshi& Hamaguchi, Eisuke& Tsutsumi, Rie…[et al.]. The Effects of Intravenous Fosaprepitant and Ondansetron for the Prevention of Postoperative Nausea and Vomiting in Neurosurgery Patients : A Prospective, Randomized, Double-Blinded Study. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-462109
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462109
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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