Pulmonary Immune-Compartment-Specific Interferon Gamma Responses in HIV-Infected Individuals with Active Tuberculosis (TB) in an Area of High TB Prevalence
المؤلفون المشاركون
Buldeo, S.
Murdoch, D. M.
Suchard, M. S.
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-06-21
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
There is a paucity of data on the pulmonary immune-compartment interferon gamma (IFNγ) response to M.
tuberculosis, particularly in settings of high tuberculosis (TB) prevalence and in HIV-coinfected individuals.
This data is necessary to understand the diagnostic potential of commercially available interferon gamma release assays (IGRAs) in both the pulmonary immune-compartment and peripheral blood.
We used intracellular cytokine staining by flow cytometry to assess the IFNγ response to purified protein derivative (PPD) and early secretory antigen 6 (ESAT6) in induced sputa (ISp) and blood samples from HIV-infected, smear-negative, TB suspects.
We found that individuals with active TB disease produced significantly less IFNγ in response to PPD in their induced sputa samples than individuals with non-active TB (control group).
This difference was not reflected in the peripheral blood, even within the CD27− CD4+ memory T lymphocyte population.
These findings suggest that progression to active TB disease may be associated with the loss of IFNγ secretion at the site of primary infection.
Our findings highlight the importance of studying pulmonary immune-compartment M.
tuberculosis specific responses to elucidate IFNγ secretion across the spectrum of TB disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Buldeo, S.& Murdoch, D. M.& Suchard, M. S.. 2012. Pulmonary Immune-Compartment-Specific Interferon Gamma Responses in HIV-Infected Individuals with Active Tuberculosis (TB) in an Area of High TB Prevalence. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-462268
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Buldeo, S.…[et al.]. Pulmonary Immune-Compartment-Specific Interferon Gamma Responses in HIV-Infected Individuals with Active Tuberculosis (TB) in an Area of High TB Prevalence. Clinical and Developmental Immunology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-462268
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Buldeo, S.& Murdoch, D. M.& Suchard, M. S.. Pulmonary Immune-Compartment-Specific Interferon Gamma Responses in HIV-Infected Individuals with Active Tuberculosis (TB) in an Area of High TB Prevalence. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-462268
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462268
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر