Immunomodulatory Effects of Aerobic Training in Obesity
المؤلفون المشاركون
Halle, Martin
Schmidt-Trucksäss, Arno
Lambert, Marius
Weis, Michael
Drexel, Verena
Summo, Claudia
Sisic, Zeljka
Emslander, Ingrid
Nickel, Thomas
Hanssen, Henner
Hoster, Eva
Hertel, Gernot
المصدر
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-03-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Introduction.
Physical inactivity and obesity are independent risk factors for atherosclerosis.
We analyzed the immunomodulatory capacity of 10-week intensified exercise training (ET) in obese and lean athletes.
Markers of the innate immune response were investigated in obese (ONE: ET≤40 km/week) and lean athletes (LNE: ET≤40 km/week and LE: ET≥55 km/week).
Methods.
Circulating dendritic cells (DC) were analyzed by flow-cytometry for BDCA-1/-2-expression.
TLR-2/-4/-7 and MyD88 were analyzed by RT-PCR and Western blot.
Circulating oxLDL levels were analyzed by ELISA.
Results.
BDCA-1 expression at baseline was lower in ONE compared to both other groups (ONE 0.15%; LNE 0.27%; LE 0.33%; P<.05), but significantly increased in ONE after training (+50%; P<.05).
In contrast, BDCA-2 expression at baseline was higher in ONE (ONE 0.25%; LNE 0.11%; LE 0.09%; P<.05) and decreased in ONE after the 10-week training period (−27%; P<.05).
Gene activations of TLR-4 and TLR-7 with corresponding protein increase were found for all three groups (P<.01/P<.05) compared to pre training.
A reduction of oxLDL levels was seen in ONE (−61%; P<.05).
Conclusions.
Intensified exercise induces an increase of BDCA-1+ DCs and TLR-4/-7 in obese athletes.
We hereby describe new immune modulatory effects, which—through regular aerobic exercise—modulate innate immunity and pro-inflammatory cytokines in obesity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nickel, Thomas& Hanssen, Henner& Emslander, Ingrid& Drexel, Verena& Hertel, Gernot& Schmidt-Trucksäss, Arno…[et al.]. 2011. Immunomodulatory Effects of Aerobic Training in Obesity. Mediators of Inflammation،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462318
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nickel, Thomas…[et al.]. Immunomodulatory Effects of Aerobic Training in Obesity. Mediators of Inflammation No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-462318
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nickel, Thomas& Hanssen, Henner& Emslander, Ingrid& Drexel, Verena& Hertel, Gernot& Schmidt-Trucksäss, Arno…[et al.]. Immunomodulatory Effects of Aerobic Training in Obesity. Mediators of Inflammation. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462318
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462318
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر