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New Insights into Ligand-Receptor Pairing and Coevolution of Relaxin Family Peptides and Their Receptors in Teleosts
المؤلفون المشاركون
Martijn, Joran
Franck, Jens
Bogerd, Jan
Good, Sara
Yegorov, Sergey
المصدر
International Journal of Evolutionary Biology
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-09-13
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Relaxin-like peptides (RLN/INSL) play diverse roles in reproductive and neuroendocrine processes in placental mammals and are functionally associated with two distinct types of receptors (RXFP) for each respective function.
The diversification of RLN/INSL and RXFP gene families in vertebrates was predominantly driven by whole genome duplications (2R and 3R).
Teleosts preferentially retained duplicates of genes putatively involved in neuroendocrine regulation, harboring a total of 10-11 receptors and 6 ligand genes, while most mammals have equal numbers of ligands and receptors.
To date, the ligand-receptor relationships of teleost Rln/Insl peptides and their receptors have largely remained unexplored.
Here, we use selection analyses based on sequence data from 5 teleosts and qPCR expression data from zebrafish to explore possible ligand-receptor pairings in teleosts.
We find support for the hypothesis that, with the exception of RLN, which has undergone strong positive selection in mammalian lineages, the ligand and receptor genes shared between mammals and teleosts appear to have similar pairings.
On the other hand, the teleost-specific receptors show evidence of subfunctionalization.
Overall, this study underscores the complexity of RLN/INSL and RXFP ligand-receptor interactions in teleosts and establishes theoretical background for further experimental work in nonmammals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Good, Sara& Yegorov, Sergey& Martijn, Joran& Franck, Jens& Bogerd, Jan. 2012. New Insights into Ligand-Receptor Pairing and Coevolution of Relaxin Family Peptides and Their Receptors in Teleosts. International Journal of Evolutionary Biology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-462436
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Good, Sara…[et al.]. New Insights into Ligand-Receptor Pairing and Coevolution of Relaxin Family Peptides and Their Receptors in Teleosts. International Journal of Evolutionary Biology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-462436
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Good, Sara& Yegorov, Sergey& Martijn, Joran& Franck, Jens& Bogerd, Jan. New Insights into Ligand-Receptor Pairing and Coevolution of Relaxin Family Peptides and Their Receptors in Teleosts. International Journal of Evolutionary Biology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-462436
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462436
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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