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Aqueous Extract of Shi-Liu-Wei-Liu-Qi-Yin Induces G2M Phase Arrest and Apoptosis in Human Bladder Carcinoma Cells via Fas and Mitochondrial Pathway
المؤلفون المشاركون
Hung, Guang-Uei
Lee, Huei-Jane
Ou, Ting-Tsz
Wu, Cheng-Hsun
Wang, Chau-Jong
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-01-03
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Shi-Liu-Wei-Liu-Qi-Yin (SLWLQY) was traditionally used to treat cancers.
However, scientific evidence of the anticancer effects still remains undefined.
In this study, we aimed to clarify the possible mechanisms of SLWLQY in treating cancer.
We evaluated the effects of SLWLQY on apoptosis-related experiments inducing in TSGH-8301 cells by (i) 3-(4,5-dimethylthiazol-zyl)-2,5-diphenylterazolium bromide (MTT) for cytotoxicity; (ii) cell-cycle analysis and (iii) western blot analysis of the G2/M-phase and apoptosis regulatory proteins.
Human bladder carcinoma TSGH-8301 cells were transplanted into BALB/c nude mice as a tumor model for evaluating the antitumor effect of SLWLQY.
Treatment of SLWLQY resulted in the G2/M phase arrest and apoptotic death in a dose-dependent manner, accompanied by a decrease in cyclin-dependent kinases (cdc2) and cyclins (cyclin B1).
SLWLQY stimulated increases in the protein expression of Fas and FasL, and induced the cleavage of caspase-3, caspase-9 and caspase-8.
The ratio of Bax/Bcl2 was increased by SLWLQY treatment.
SLWLQY markedly reduced tumor size in TSGH-8301 cells-xenografted tumor tissues.
In the tissue specimen, SLWLQY up-regulated the expression of Fas, FasL and Bax proteins, and down-regulated Bcl2 as well as in in vitro assay.
Our results showed that SLWLQY reduced tumor growth, caused cell-cycle arrest and apoptosis in TSGH-8301 cells via the Fas and mitochondrial pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ou, Ting-Tsz& Wang, Chau-Jong& Hung, Guang-Uei& Wu, Cheng-Hsun& Lee, Huei-Jane. 2011. Aqueous Extract of Shi-Liu-Wei-Liu-Qi-Yin Induces G2M Phase Arrest and Apoptosis in Human Bladder Carcinoma Cells via Fas and Mitochondrial Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462511
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ou, Ting-Tsz…[et al.]. Aqueous Extract of Shi-Liu-Wei-Liu-Qi-Yin Induces G2M Phase Arrest and Apoptosis in Human Bladder Carcinoma Cells via Fas and Mitochondrial Pathway. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-462511
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ou, Ting-Tsz& Wang, Chau-Jong& Hung, Guang-Uei& Wu, Cheng-Hsun& Lee, Huei-Jane. Aqueous Extract of Shi-Liu-Wei-Liu-Qi-Yin Induces G2M Phase Arrest and Apoptosis in Human Bladder Carcinoma Cells via Fas and Mitochondrial Pathway. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462511
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462511
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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