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Antiphospholipid Antibodies in Women Undergoing In Vitro Fertilization Treatment : Clinical Value of IgA Anti-β2glycoprotein I Antibodies Determination
المؤلفون المشاركون
Courbiere, Blandine
Bardin, Nathalie
Despierres, Laura
Paulmyer-Lacroix, Odile
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-05-25
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Implantation failure could be related to antiphospholipid antibodies (aPL).
We retrospectively analyzed the usefulness of aPL determination in women undergoing IVF.
Conventional aPL of the antiphospholipid syndrome, lupus anticoagulant (LA), anticardiolipin antibodies (aCL), anti-β2glycoprotein I (aβ2GPI) antibodies, and IgG and IgM isotypes as well as IgA isotype were analyzed in women presenting with at least two implantation failures after in vitro fertilization (IVF).
In a population of 40 IVF patients, a total prevalence of 20% (8/40) of aPL was found, significantly different from that of the control population (100 healthy blood donors, P<0.0005).
Among the panels of aPL tested, aβ2GPI IgA antibodies were the most prevalent (62.5% 5/8), significantly higher in IVF patients (12.5%, 5/40) than in controls (1%, 1/100) (P=0.01).
No difference according to the numbers of IVF attempts and success of embryo implantation was found between aPL positive and negative IVF patients.
In contrast, no accomplished pregnancy with full-term live birth was observed in aPL positive IVF patients.
Altogether our data led us to propose aPL assessment, in particular aβ2GPI IgA antibodies, in support of IVF treated women.
In a perspective way, an early aPL detection could be the basis for defining novel therapeutic strategy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Paulmyer-Lacroix, Odile& Despierres, Laura& Courbiere, Blandine& Bardin, Nathalie. 2014. Antiphospholipid Antibodies in Women Undergoing In Vitro Fertilization Treatment : Clinical Value of IgA Anti-β2glycoprotein I Antibodies Determination. BioMed Research International،Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-462745
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Paulmyer-Lacroix, Odile…[et al.]. Antiphospholipid Antibodies in Women Undergoing In Vitro Fertilization Treatment : Clinical Value of IgA Anti-β2glycoprotein I Antibodies Determination. BioMed Research International No. 2014 (2014), pp.1-5.
https://search.emarefa.net/detail/BIM-462745
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Paulmyer-Lacroix, Odile& Despierres, Laura& Courbiere, Blandine& Bardin, Nathalie. Antiphospholipid Antibodies in Women Undergoing In Vitro Fertilization Treatment : Clinical Value of IgA Anti-β2glycoprotein I Antibodies Determination. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-5.
https://search.emarefa.net/detail/BIM-462745
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462745
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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