Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection
المؤلفون المشاركون
Marchetti, Giulia
Sinigaglia, Elisabetta
Tincati, Camilla
Pacioni, Carlotta
Bai, Francesca
d’Arminio Monforte, Antonella
Merlini, Esther
Carpani, Giovanni
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-10-27
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objectives.
We investigated immune phenotypes of HIV+ patients who present late, considering late presenters (LPs, CD4+ < 350/μL and/or AIDS), advanced HIV disease (AHD, CD4+ < 200/μL and/or AIDS), and AIDS presenters (AIDS-defining condition at presentation, independently from CD4+).
Methods.
Patients newly diagnosed with HIV at our clinic between 2007–2011 were enrolled.
Mann-Whitney/Chi-squared tests and logistic regression were used for statistics.
Results.
275 patients were newly diagnosed with HIV between January/2007–March/2011.
130 (47%) were LPs, 79 (29%) showed AHD, and 49 (18%) were AIDS presenters.
LP, AHD, and AIDS presenters were older and more frequently heterosexuals.
Higher CD8+%, lower CD127+CD4+%, higher CD95+CD8+%, CD38+CD8+%, and CD45R0+CD38+CD8+% characterized LP/AHD/AIDS presentation.
In multivariate analysis, older age, heterosexuality, higher CD8+%, and lower CD127+CD4+% were confirmed associated with LP/AHD.
Lower CD4+ and higher CD38+CD8+% resulted independently associated with AIDS presentation.
Conclusions.
CD127 downregulation and immune activation characterize HIV+ patients presenting late and would be studied as additional markers of late presentation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bai, Francesca& Tincati, Camilla& Merlini, Esther& Pacioni, Carlotta& Sinigaglia, Elisabetta& Carpani, Giovanni…[et al.]. 2011. Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection. AIDS Research and Treatment،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-462758
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bai, Francesca…[et al.]. Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection. AIDS Research and Treatment No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-462758
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bai, Francesca& Tincati, Camilla& Merlini, Esther& Pacioni, Carlotta& Sinigaglia, Elisabetta& Carpani, Giovanni…[et al.]. Reduced Central Memory CD4+ T Cells and Increased T-Cell Activation Characterise Treatment-Naive Patients Newly Diagnosed at Late Stage of HIV Infection. AIDS Research and Treatment. 2011. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-462758
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462758
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر