Synergistic Effects of Orbital Shear Stress on In Vitro Growth and Osteogenic Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells
المؤلفون المشاركون
Kim, Jangho
Choung, Pill-Hoon
Seonwoo, Hoon
Chung, Jong Hoon
Hexiu, Jin
Lim, Ki Taek
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-01-14
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Cellular behavior is dependent on a variety of physical cues required for normal tissue function.
In order to mimic native tissue environments, human alveolar bone-derived mesenchymal stem cells (hABMSCs) were exposed to orbital shear stress (OSS) in a low-speed orbital shaker.
The synergistic effects of OSS on proliferation and differentiation of hABMSCs were investigated.
In particular, we induced the osteoblastic differentiation of hABMSCs cultured in the absence of OM by exposing hABMSCs to OSS (0.86–1.51 dyne/cm2).
Activation of Cx43 was associated with exposure of hABMSCs to OSS.
The viability of cells stimulated for 10, 30, 60, 120, and 180 min/day increased by approximately 10% compared with that of control.
The OSS groups with stimulation of 10, 30, and 60 min/day had more intense mineralized nodules compared with the control group.
In quantification of vascular endothelial growth factor (VEGF) and bone morphogenetic protein-2 (BMP-2) protein, VEGF protein levels under stimulation for 10, 60, and 180 min/day and BMP-2 levels under stimulation for 60, 120, and 180 min/day were significantly different compared with those of the control.
In conclusion, the results indicated that exposing hABMSCs to OSS enhanced their differentiation and maturation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lim, Ki Taek& Hexiu, Jin& Kim, Jangho& Seonwoo, Hoon& Choung, Pill-Hoon& Chung, Jong Hoon. 2014. Synergistic Effects of Orbital Shear Stress on In Vitro Growth and Osteogenic Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-462932
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lim, Ki Taek…[et al.]. Synergistic Effects of Orbital Shear Stress on In Vitro Growth and Osteogenic Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells. BioMed Research International No. 2014 (2014), pp.1-18.
https://search.emarefa.net/detail/BIM-462932
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lim, Ki Taek& Hexiu, Jin& Kim, Jangho& Seonwoo, Hoon& Choung, Pill-Hoon& Chung, Jong Hoon. Synergistic Effects of Orbital Shear Stress on In Vitro Growth and Osteogenic Differentiation of Human Alveolar Bone-Derived Mesenchymal Stem Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-18.
https://search.emarefa.net/detail/BIM-462932
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462932
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر