A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens
المؤلفون المشاركون
Johnson, Rudd C.
Reese, Kaleb A.
Mullen, Valerie M.
Mitev, Georgi M.
Lupfer, Christopher
Geller, Bruce L.
Pastey, Manoj
المصدر
Veterinary Medicine International
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-05-22
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
A cost-effective and efficacious influenza vaccine for use in commercial poultry farms would help protect against avian influenza outbreaks.
Current influenza vaccines for poultry are expensive and subtype specific, and therefore there is an urgent need to develop a universal avian influenza vaccine.
We have constructed a live bacterial vaccine against avian influenza by expressing a conserved peptide from the ectodomain of M2 antigen (M2e) on the surface of Lactococcus lactis (LL).
Chickens were vaccinated intranasally with the lactococcal vaccine (LL-M2e) or subcutaneously with keyhole-limpet-hemocyanin conjugated M2e (KLH-M2e).
Vaccinated and nonvaccinated birds were challenged with high pathogenic avian influenza virus A subtype H5N2.
Birds vaccinated with LL-M2e or KLH-M2e had median survival times of 5.5 and 6.0 days, respectively, which were significantly longer than non-vaccinated birds (3.5 days).
Birds vaccinated subcutaneously with KLH-M2e had a lower mean viral burden than either of the other two groups.
However, there was a significant correlation between the time of survival and M2e-specific serum IgG.
The results of these trials show that birds in both vaccinated groups had significantly (P<0.05) higher median survival times than non-vaccinated birds and that this protection could be due to M2e-specific serum IgG.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Reese, Kaleb A.& Lupfer, Christopher& Johnson, Rudd C.& Mitev, Georgi M.& Mullen, Valerie M.& Geller, Bruce L.…[et al.]. 2013. A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens. Veterinary Medicine International،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462945
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Reese, Kaleb A.…[et al.]. A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens. Veterinary Medicine International No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-462945
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Reese, Kaleb A.& Lupfer, Christopher& Johnson, Rudd C.& Mitev, Georgi M.& Mullen, Valerie M.& Geller, Bruce L.…[et al.]. A Novel Lactococcal Vaccine Expressing a Peptide from the M2 Antigen of H5N2 Highly Pathogenic Avian Influenza A Virus Prolongs Survival of Vaccinated Chickens. Veterinary Medicine International. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-462945
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462945
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر