Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae)‎ in Rodents

المؤلفون المشاركون

Gadhi, Chemseddoha A.
El Jahiri, Younes
El Mansouri, Abdellah
Zrara, Ibtissam
Lakmichi, Hind
Ezoubeiri, Aicha
Bakhtaoui, Fatima Zahra
Loutfi, Kenza

المصدر

Evidence-Based Complementary and Alternative Medicine

العدد

المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-10، 10ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2010-09-07

دولة النشر

مصر

عدد الصفحات

10

التخصصات الرئيسية

الطب البشري

الملخص EN

Corrigiola telephiifolia Pourr.

(Caryophyllaceae) is a Moroccan medicinal plant.

Despite its popular usage, no study has been published concerning its toxicological profile.

The acute toxicity of C.

telephiifolia root extract was evaluated by giving it orally to mice at single doses of 5000, 10000, and 14000 mg/kg bodyweight.

The extract was also administered at doses of 5, 70, and 2000 mg/kg bodyweight per day to rats for a forty-day toxicity study.

No mortality or signs of toxicity were observed in the acute study.

In the forty-day study in rats, the extract at 5 mg/kg/day showed no toxicological effects in either sex.

At 70 mg/kg/day, the treated group differed from the control only by a significant decrease in serum concentrations of sodium and chloride ions (P<.05).

At the dose of 2000 mg/kg/day, the extract significantly increased the serum concentrations of creatinine, alkaline phosphatase, gamma-glutamyltransferase and phosphorus (P<.05) all suggestive of functional nephrotoxicity and hepatotoxicity.

The relative bodyweight of both sexes decreased at the dose of 2000 mg/kg/day, with a fast recovery for males.

Histological examination did not reveal any treatment-related effects.

In conclusion, Corrigiola extract appears safe at the doses used ethno-medicinally.

Much higher doses pose toxicological risks.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Lakmichi, Hind& Bakhtaoui, Fatima Zahra& Gadhi, Chemseddoha A.& Ezoubeiri, Aicha& El Jahiri, Younes& El Mansouri, Abdellah…[et al.]. 2010. Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462965

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Lakmichi, Hind…[et al.]. Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-10.
https://search.emarefa.net/detail/BIM-462965

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Lakmichi, Hind& Bakhtaoui, Fatima Zahra& Gadhi, Chemseddoha A.& Ezoubeiri, Aicha& El Jahiri, Younes& El Mansouri, Abdellah…[et al.]. Toxicity Profile of the Aqueous Ethanol Root Extract of Corrigiola telephiifolia Pourr. (Caryophyllaceae) in Rodents. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-10.
https://search.emarefa.net/detail/BIM-462965

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-462965