Insights into the In Vivo Regulation of Glutamate Dehydrogenase from the Foot Muscle of an Estivating Land Snail
المؤلفون المشاركون
Dawson, Neal J.
Bell, Ryan A. V.
Storey, Kenneth B.
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-26
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Land snails, Otala lactea, survive in seasonally hot and dry environments by entering a state of aerobic torpor called estivation.
During estivation, snails must prevent excessive dehydration and reorganize metabolic fuel use so as to endure prolonged periods without food.
Glutamate dehydrogenase (GDH) was hypothesized to play a key role during estivation as it shuttles amino acid carbon skeletons into the Krebs cycle for energy production and is very important to urea biosynthesis (a key molecule used for water retention).
Analysis of purified foot muscle GDH from control and estivating conditions revealed that estivated GDH was approximately 3-fold more active in catalyzing glutamate deamination as compared to control.
This kinetic difference appears to be regulated by reversible protein phosphorylation, as indicated by ProQ Diamond phosphoprotein staining and incubations that stimulate endogenous protein kinases and phosphatases.
The increased activity of the high-phosphate form of GDH seen in the estivating land snail foot muscle correlates well with the increased use of amino acids for energy and increased synthesis of urea for water retention during prolonged estivation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bell, Ryan A. V.& Dawson, Neal J.& Storey, Kenneth B.. 2012. Insights into the In Vivo Regulation of Glutamate Dehydrogenase from the Foot Muscle of an Estivating Land Snail. Enzyme Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-462991
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bell, Ryan A. V.…[et al.]. Insights into the In Vivo Regulation of Glutamate Dehydrogenase from the Foot Muscle of an Estivating Land Snail. Enzyme Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-462991
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bell, Ryan A. V.& Dawson, Neal J.& Storey, Kenneth B.. Insights into the In Vivo Regulation of Glutamate Dehydrogenase from the Foot Muscle of an Estivating Land Snail. Enzyme Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-462991
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-462991
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر