TRIM29 as a Novel Biomarker in Pancreatic Adenocarcinoma
المؤلفون المشاركون
Sun, Hongli
Han, Bing
Dai, Xianwei
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-04-20
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Background and Aim.
Tripartite motif-containing 29 (TRIM29) is structurally a member of the tripartite motif family of proteins and is involved in diverse human cancers.
However, its role in pancreatic cancer remains unclear.
Methods.
The expression pattern of TRIM29 in pancreatic ductal adenocarcinoma was assessed by immunocytochemistry.
Multivariate logistic regression analysis was used to investigate the association between TRIM29 and clinical characteristics.
In vitro analyses by scratch wound healing assay and invasion assays were performed using the pancreatic cancer cell lines.
Results.
Immunohistochemical analysis showed TRIM29 expression in pancreatic cancer tissues was significantly higher (n=186) than that in matched adjacent nontumor tissues.
TRIM29 protein expression was significantly correlated with lymph node metastasis (P=0.019).
Patients with positive TRIM29 expression showed both shorter overall survival and shorter recurrence-free survival than those with negative TRIM29 expression.
Multivariate analysis revealed that TRIM29 was an independent factor for pancreatic cancer over survival (HR=2.180, 95% CI: 1.324–4.198, P=0.011).
In vitro, TRIM29 knockdown resulted in inhibition of pancreatic cancer cell proliferation, migration, and invasion.
Conclusions.
Our results indicate that TRIM29 promotes tumor progression and may be a novel prognostic marker for pancreatic ductal adenocarcinoma.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Hongli& Dai, Xianwei& Han, Bing. 2014. TRIM29 as a Novel Biomarker in Pancreatic Adenocarcinoma. Disease Markers،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-463041
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Hongli…[et al.]. TRIM29 as a Novel Biomarker in Pancreatic Adenocarcinoma. Disease Markers No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-463041
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Hongli& Dai, Xianwei& Han, Bing. TRIM29 as a Novel Biomarker in Pancreatic Adenocarcinoma. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-463041
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463041
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر