Fragmentation Pathways of Trifluoroacetyl Derivatives of Methamphetamine, Amphetamine, and Methylenedioxyphenylalkylamine Designer Drugs by Gas ChromatographyMass Spectrometry
المؤلفون المشاركون
Kumazawa, Takeshi
Suzuki, Osamu
Hasegawa, Chika
Sato, Keizo
Lee, Xiao-Pen
Seno, Hiroshi
Uchigasaki, Seisaku
Hara, Kenji
المصدر
International Journal of Spectroscopy
العدد
المجلد 2011، العدد 2011 (31 ديسمبر/كانون الأول 2011)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-08-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Methamphetamine (MA), amphetamine (AM), and the methylenedioxyphenylalkylamine designer drugs, such as 3,4-methylenedioxymethamphetamine (MDMA), 3,4-methylenedioxyethylamphetamine (MDEA), N-methyl-1-(3,4-methylenedioxyphenyl)-2-butanamine (MBDB), 3,4-methylenedioxyamphetamine (MDA), and 3,4-(methylenedioxyphenyl)-2-butanamine (BDB), are widely abused as psychedelics.
In this paper, these compounds were derivatized with trifluoroacetic (TFA) anhydride and analyzed by gas chromatography/mass spectrometry using electron ionization in positive mode.
Gas chromatographic separation for TFA derivatives of all compounds was successfully resolved using an Equity-5 fused silica capillary column with a poly (5% diphenyl-95% dimethylsiloxane) stationary phase.
Base peaks or prominent peaks of MA, AM, MDMA, MDEA, MBDB, MDA, and BDB appeared at m/z 154, 140, 154, 168, 168, 135, and 135, respectively.
These occurred due to α-cleavage from the amide nitrogen, splitting into the TFA imine species and benzyl or methylenedioxybenzyl cations.
Further prominent fragment ions at m/z 118 for MA and AM, m/z 162 for MDMA, MDEA, and MDA, and m/z 176 for MBDB and BDB were produced by cleavage of the phenylpropane or methylenedioxypropane hydrocarbon radical cation via a hydrogen rearrangement.
These fragmentation pathways for the TFA derivatives of all the compounds are summarized and illustrated in this paper.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kumazawa, Takeshi& Hara, Kenji& Hasegawa, Chika& Uchigasaki, Seisaku& Lee, Xiao-Pen& Seno, Hiroshi…[et al.]. 2011. Fragmentation Pathways of Trifluoroacetyl Derivatives of Methamphetamine, Amphetamine, and Methylenedioxyphenylalkylamine Designer Drugs by Gas ChromatographyMass Spectrometry. International Journal of Spectroscopy،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-463072
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kumazawa, Takeshi…[et al.]. Fragmentation Pathways of Trifluoroacetyl Derivatives of Methamphetamine, Amphetamine, and Methylenedioxyphenylalkylamine Designer Drugs by Gas ChromatographyMass Spectrometry. International Journal of Spectroscopy No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-463072
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kumazawa, Takeshi& Hara, Kenji& Hasegawa, Chika& Uchigasaki, Seisaku& Lee, Xiao-Pen& Seno, Hiroshi…[et al.]. Fragmentation Pathways of Trifluoroacetyl Derivatives of Methamphetamine, Amphetamine, and Methylenedioxyphenylalkylamine Designer Drugs by Gas ChromatographyMass Spectrometry. International Journal of Spectroscopy. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-463072
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463072
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر