Novel Neurovascular Protective Agents : Effects of INV-155, INV-157, INV-159, and INV-161 versus Lipoic Acid and Captopril in a Rat Stroke Model
المؤلفون المشاركون
Connell, Barry J.
Khan, Bobby Varkey
Rajagopal, Desikan
Saleh, Tarek M.
المصدر
Cardiology Research and Practice
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-01-04
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Lipoic acid (LA), which has significant antioxidant properties, may also function as a potent neuroprotectant.
The synthetic compounds INV-155, INV-157, INV-159, and INV-161 are physiochemical combinations of lipoic acid and captopril.
We sought to determine if these compounds have neuroprotective potential following middle cerebral artery occlusion (MCAO) in rats.
Methods.
Male Sprague-Dawley rats were injected intravenously with captopril (1–50 mg/kg) 30 minutes prior to MCAO.
Blood pressure, heart rate, baroreceptor reflex sensitivity, and infarct size were measured.
In addition, dose response effect on infarct size and cardiovascular parameters was determined using INV-155, INV-157, INV-159, and INV-161 and compared to captopril and LA.
Results.
Pretreatment with captopril and LA at all doses tested was neuroprotective.
The compounds INV-159 (0.5–10 mg/kg) and INV-161 (1–10 mg/kg) produced a significant,dose-dependent decrease in infarct size.
In contrast, INV-155 and INV-157 had no effect on infarct size.
Conclusions.
Combined pretreatment with captopril potentiated the neuroprotective benefit observed following LA alone.
Both INV-159 and INV-161 were also neuroprotective.
These results suggest that patients taking combinations of captopril and LA, either as combination therapy or in the form of INV-159 or INV-161, may also benefit from significant protection against cerebral infarction.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Connell, Barry J.& Khan, Bobby Varkey& Rajagopal, Desikan& Saleh, Tarek M.. 2012. Novel Neurovascular Protective Agents : Effects of INV-155, INV-157, INV-159, and INV-161 versus Lipoic Acid and Captopril in a Rat Stroke Model. Cardiology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-463160
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Connell, Barry J.…[et al.]. Novel Neurovascular Protective Agents : Effects of INV-155, INV-157, INV-159, and INV-161 versus Lipoic Acid and Captopril in a Rat Stroke Model. Cardiology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-463160
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Connell, Barry J.& Khan, Bobby Varkey& Rajagopal, Desikan& Saleh, Tarek M.. Novel Neurovascular Protective Agents : Effects of INV-155, INV-157, INV-159, and INV-161 versus Lipoic Acid and Captopril in a Rat Stroke Model. Cardiology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-463160
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463160
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر