IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense
المؤلفون المشاركون
Ngotho, Maina
Wangari Maina, Naomi
Kagira, John Maina
Nyawira Maranga, Dawn
Muturi Karanja, Simon
Kinyanjui, Christopher Kariuki
المصدر
Clinical and Developmental Immunology
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-30
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The management of human African trypanosomiasis (HAT) is constrained by lack of simple-to-use diagnostic, staging, and treatment tools.
The search for novel biomarkers is, therefore, essential in the fight against HAT.
The current study aimed at investigating the potential of IL-6 as an adjunct parameter for HAT stage determination in vervet monkey model.
Four adult vervet monkeys (Chlorocebus aethiops) were experimentally infected with Trypanosoma brucei rhodesiense and treated subcuratively at 28 days after infection (dpi) to induce late stage disease.
Three noninfected monkeys formed the control group.
Cerebrospinal fluid (CSF) and blood samples were obtained at weekly intervals and assessed for various biological parameters.
A typical HAT-like infection was observed.
The late stage was characterized by significant (P<0.05) elevation of CSF IL-6, white blood cell count, and total protein starting 35 dpi with peak levels of these parameters coinciding with relapse parasitaemia.
Brain immunohistochemical staining revealed an increase in brain glial fibrillary acidic protein expression indicative of reactive astrogliosis in infected animals which were euthanized in late-stage disease.
The elevation of IL-6 in CSF which accompanied other HAT biomarkers indicates onset of parasite neuroinvasion and show potential for use as an adjunct late-stage disease biomarker in the Rhodesian sleeping sickness.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nyawira Maranga, Dawn& Kagira, John Maina& Kinyanjui, Christopher Kariuki& Muturi Karanja, Simon& Wangari Maina, Naomi& Ngotho, Maina. 2013. IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-463267
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nyawira Maranga, Dawn…[et al.]. IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense. Clinical and Developmental Immunology No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-463267
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nyawira Maranga, Dawn& Kagira, John Maina& Kinyanjui, Christopher Kariuki& Muturi Karanja, Simon& Wangari Maina, Naomi& Ngotho, Maina. IL-6 is Upregulated in Late-Stage Disease in Monkeys Experimentally Infected with Trypanosoma brucei rhodesiense. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-463267
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463267
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر