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The Association between Hypertension and Dementia in the Elderly
المؤلفون المشاركون
Miki, Tetsuro
Igase, Michiya
Kohara, Katsuhiko
المصدر
International Journal of Hypertension
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2011-11-03
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Hypertension (HT) and dementia are common disorders in the elderly.
HT in the elderly is associated with increased occurrence rates of dementia including Alzheimer's disease (AD) and vascular dementia (VaD).
In connection to this, some studies have suggested that HT in old age correlates with the pathogenesis of dementia.
Since HT is potentially reversible, a number of randomized trials have examined whether antihypertensive treatment may help in preventing dementia occurrence.
We review five studies, all using subjects 60 years or older, which investigated different antihypertensive pharmacological treatments.
Data from two trials (Syst-Eur, PROGRESS) open the way toward the prevention of dementia (AD or VaD) by antihypertensive treatments.
In the Syst-Eur study, with the dihydropyridine calcium antagonists, a reduction in both types of dementia was demonstrated (risk reduction 55%).
The PROGRESS study showed that the use of angiotensin-converting enzyme inhibitors (ACEIs), with or without diuretics, resulted in decrease incidence of stroke-related dementia (risk reduction 19%), but dementia without stroke was not reduced.
In contrast, the SHEP trial, treatment with a chlorthalidone-based antihypertensive regimen, did not significantly reduced the incidence of dementia.
The SCOPE study (candesartan or hydrochlorothiazide versus placebo) and the HYVET-COG study (indapamide or perindopril versus placebo) found no significant difference between the active treatment and placebo group on the incidence of dementia.
We found conflicting results regarding treatment benefits in dementia prevention.
Recent clinical trials and studies on animal models suggest that blockades of RAS system could have reduced cognitive decline seen in Alzheimer's disease and vascular dementia.
Future trials primarily designed to investigate the effects of antihypertensive agents on impaired cognition are needed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Igase, Michiya& Kohara, Katsuhiko& Miki, Tetsuro. 2011. The Association between Hypertension and Dementia in the Elderly. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-463286
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Igase, Michiya…[et al.]. The Association between Hypertension and Dementia in the Elderly. International Journal of Hypertension No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-463286
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Igase, Michiya& Kohara, Katsuhiko& Miki, Tetsuro. The Association between Hypertension and Dementia in the Elderly. International Journal of Hypertension. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-463286
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463286
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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