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Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma : Report of a Rare Case and Literature Review
المؤلفون المشاركون
Wieczorek, Kathrin
Mohm, Johannes
Hamann, Christine
Platzek, Ivan
Ehninger, Gerhard
Schuler, Markus K.
Richter, Stephan
Beuthien-Baumann, Bettina
المصدر
Case Reports in Oncological Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-01-16
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Pleomorphic sarcoma is an aggressive soft tissue sarcoma.
In patients with high-risk extremity sarcomas, the significant survival benefits conferred by an intense regimen of neoadjuvant chemoradiotherapy and surgery were reported.
To our knowledge, this is the first report in the literature of the neoadjuvant use of trabectedin in a patient with high-grade pleomorphic sarcoma, ineligible for standard neoadjuvant combination therapy with an anthracycline-based regimen.
Case Presentation.
Here we present a 58-year-old White male with a large tumor in the left thigh, but with no signs of metastases.
Owing to the history of severe heart attack, three cycles of neoadjuvant trabectedin were administrated to achieve surgically wide margins.
After two cycles, an 18F-FDG-PET showed a large proportion of the central tumor area was without metabolic activity.
According to RECIST and Choi criteria, the tumor was stable.
After the third cycle of trabectedin, the patient underwent a complete resection, which revealed completely necrotic high-grade pleomorphic sarcoma (stage pT2b), with only a small vital area.
Conclusion.
The present paper on a promising treatment with neoadjuvant trabectedin of patients with high-grade pleomorphic sarcoma might suggest that such treatment approach may provide a greater chance of cure and survival of such patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schuler, Markus K.& Richter, Stephan& Platzek, Ivan& Beuthien-Baumann, Bettina& Wieczorek, Kathrin& Hamann, Christine…[et al.]. 2013. Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma : Report of a Rare Case and Literature Review. Case Reports in Oncological Medicine،Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-463301
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schuler, Markus K.…[et al.]. Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma : Report of a Rare Case and Literature Review. Case Reports in Oncological Medicine No. 2013 (2013), pp.1-5.
https://search.emarefa.net/detail/BIM-463301
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schuler, Markus K.& Richter, Stephan& Platzek, Ivan& Beuthien-Baumann, Bettina& Wieczorek, Kathrin& Hamann, Christine…[et al.]. Trabectedin in the Neoadjuvant Treatment of High-Grade Pleomorphic Sarcoma : Report of a Rare Case and Literature Review. Case Reports in Oncological Medicine. 2013. Vol. 2013, no. 2013, pp.1-5.
https://search.emarefa.net/detail/BIM-463301
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463301
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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