![](/images/graphics-bg.png)
The Cell Wall Sensors Mtl1, Wsc1, and Mid2 Are Required for Stress-Induced Nuclear to Cytoplasmic Translocation of Cyclin C and Programmed Cell Death in Yeast
المؤلفون المشاركون
Daly, Ira
Cooper, Katrina F.
Jin, Chunyan
Strich, Randy
Parshin, Andrey V.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-10-23
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Mtl1 is a member of a cell wall sensor family that monitors cell wall integrity in budding yeast.
In response to cell wall stress, Mtl1 activates the cell wall integrity (CWI) MAP kinase pathway which transmits this signal to the nucleus to effect changes in gene expression.
One target of the CWI MAP kinase is cyclin C, a negative regulator of stress response genes.
CWI activation results in cyclin C relocalization from the nucleus to the cytoplasm where it stimulates programmed cell death (PCD) before it is destroyed.
This report demonstrates that under low oxidative stress conditions, a combination of membrane sensors, Mtl1 and either Wsc1 or Mid2, are required jointly to transmit the oxidative stress signal to initiate cyclin C destruction.
However, when exposed to elevated oxidative stress, additional pathways independent of these three sensor proteins are activated to destroy cyclin C.
In addition, N-glycosylation is important for Mtl1 function as mutating the receptor residue (Asn42) or an enzyme required for synthesis of N-acetylglucosamine (Gfa1) reduces sensor activity.
Finally, combining gfa1-1 with the cyclin C null allele induces a severe synthetic growth defect.
This surprising result reveals a previously unknown genetic interaction between cyclin C and plasma membrane integrity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Chunyan& Parshin, Andrey V.& Daly, Ira& Strich, Randy& Cooper, Katrina F.. 2013. The Cell Wall Sensors Mtl1, Wsc1, and Mid2 Are Required for Stress-Induced Nuclear to Cytoplasmic Translocation of Cyclin C and Programmed Cell Death in Yeast. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-463305
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Chunyan…[et al.]. The Cell Wall Sensors Mtl1, Wsc1, and Mid2 Are Required for Stress-Induced Nuclear to Cytoplasmic Translocation of Cyclin C and Programmed Cell Death in Yeast. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-15.
https://search.emarefa.net/detail/BIM-463305
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Chunyan& Parshin, Andrey V.& Daly, Ira& Strich, Randy& Cooper, Katrina F.. The Cell Wall Sensors Mtl1, Wsc1, and Mid2 Are Required for Stress-Induced Nuclear to Cytoplasmic Translocation of Cyclin C and Programmed Cell Death in Yeast. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-15.
https://search.emarefa.net/detail/BIM-463305
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463305
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)