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Evaluation of ENA-6 Profile by ELISA Immunoassay in Patients with Systemic Lupus Erythematodes
المؤلفون المشاركون
Grcic, Nerima
Jukic, Tomislav
Zecevic, Lamija
Avdagic, Nesina
Karamehic, Jasenko
Aganovic-Musinovic, Izeta
Zaciragic, Asija
Svrakic, Suvada
Gavrankapetanovic, Faris
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-11
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Autoimmune diseases occur in 3−5% of the population.
Study included 30 patients with clinically diagnosed SLE and 30 healthy controls (American college of Rheumatology, 1997).
SLE was diagnosed according to criteria issued in 1997 by the American College of Rheumatology (ACR).
The aim of this study was to evaluate concentration values of each antigen of ENA-6 profile in SLE, to investigate possible correlation between the concentration of Sm antibodies and CIC, and to test their use as possible immunobiological markers in SLE.
Furthermore, the aim of our study was to determine whether there is a correlation between Sm antibodies and CIC and SLE activity.
The results revealed that all of these ENA-6 and Sm antibodies as biomarkers complement diagnoses of active SLE but their use as solo markers does not allow classifying patients with SLE.
Our study has shown that based on calculations from ROC curves, Sm/RNP was clearly a very important marker for diagnosis of SLE (cut off ≥ 9.56 EU, AUC 0,942).
The high incidence of Scl-70 (10%) reactivity suggests that ELISA monitoring of this antibody produces more false positive results than other multiplex assay.
An important conclusion that can be drawn from the results of our study is that laboratory tests are no more effective than clinical examination for detecting disease relapse, but are helpful in the confirmation of SLE activity.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Aganovic-Musinovic, Izeta& Karamehic, Jasenko& Zecevic, Lamija& Gavrankapetanovic, Faris& Avdagic, Nesina& Zaciragic, Asija…[et al.]. 2012. Evaluation of ENA-6 Profile by ELISA Immunoassay in Patients with Systemic Lupus Erythematodes. Autoimmune Diseases،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-463382
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Aganovic-Musinovic, Izeta…[et al.]. Evaluation of ENA-6 Profile by ELISA Immunoassay in Patients with Systemic Lupus Erythematodes. Autoimmune Diseases No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-463382
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Aganovic-Musinovic, Izeta& Karamehic, Jasenko& Zecevic, Lamija& Gavrankapetanovic, Faris& Avdagic, Nesina& Zaciragic, Asija…[et al.]. Evaluation of ENA-6 Profile by ELISA Immunoassay in Patients with Systemic Lupus Erythematodes. Autoimmune Diseases. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-463382
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463382
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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