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Characterization of the Protective HIV-1 CTL Epitopes and the Corresponding HLA Class I Alleles : A Step towards Designing CTL Based HIV-1 Vaccine
المؤلفون المشاركون
Chakraborty, Sajib
Rahman, Taibur
Chakravorty, Rajib
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-03-18
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Human immunodeficiency virus (HIV) possesses a major threat to the human life largely due to the unavailability of an efficacious vaccine and poor access to the antiretroviral drugs against this deadly virus.
High mutation rate in the viral genome underlying the antigenic variability of the viral proteome is the major hindrance as far as the antibody based vaccine development is concerned.
Although the exact mechanism by which CTL epitopes and the restricting HLA alleles mediate their action towards slow disease progression is still not clear, the important CTL restricted epitopes for controlling viral infections can be utilized in future vaccine design.
This study was designed for the characterization the HIV-1 optimal CTL epitopes and their corresponding HLA alleles.
CTL epitope cluster distribution analysis revealed only two HIV-1 proteins, namely, Nef and Gag, which have significant cluster forming capacity.
We have found the role of specific HLA supertypes such as HLA B*07, HLA B*58, and HLA A*03 in selecting the hydrophobic and conserved amino acid positions within Nef and Gag proteins, to be presented as epitopes.
The analyses revealed that the clusters of optimal epitopes for Nef and p24 proteins of HIV-1 could potentially serve as a source of vaccine.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chakraborty, Sajib& Rahman, Taibur& Chakravorty, Rajib. 2014. Characterization of the Protective HIV-1 CTL Epitopes and the Corresponding HLA Class I Alleles : A Step towards Designing CTL Based HIV-1 Vaccine. Advances in Virology،Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-463413
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chakraborty, Sajib…[et al.]. Characterization of the Protective HIV-1 CTL Epitopes and the Corresponding HLA Class I Alleles : A Step towards Designing CTL Based HIV-1 Vaccine. Advances in Virology No. 2014 (2014), pp.1-17.
https://search.emarefa.net/detail/BIM-463413
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chakraborty, Sajib& Rahman, Taibur& Chakravorty, Rajib. Characterization of the Protective HIV-1 CTL Epitopes and the Corresponding HLA Class I Alleles : A Step towards Designing CTL Based HIV-1 Vaccine. Advances in Virology. 2014. Vol. 2014, no. 2014, pp.1-17.
https://search.emarefa.net/detail/BIM-463413
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463413
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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