![](/images/graphics-bg.png)
Elevated Angiopoietin-1 Serum Levels in Patients with Alzheimer’s Disease
المؤلفون المشاركون
Laske, Christoph
Stransky, Elke
Leyhe, Thomas
Köhler, Niklas
Schreitmüller, Brigitte
المصدر
International Journal of Alzheimer's Disease
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-10
دولة النشر
مصر
عدد الصفحات
5
التخصصات الرئيسية
الملخص EN
Background.
Alzheimer's disease (AD) is the most common cause of dementia in the elderly.
AD is characterized by the accumulation of amyloid plaques and neurofibrillary tangles and by massive neuronal loss in the brain.
There is epidemiologic and pathologic evidence that AD is associated with vascular risk factors and vascular diseases, contributing to cerebral hypoperfusion with consecutive stimulation of angiogenesis and upregulation of proangiogenic factors such as Angiopoietin-1 (Ang-1).
Methods.
In the present study, we measured Ang-1 serum levels in 42 patients with AD, 20 patients with mild cognitive impairment (MCI), and in 40 healthy elderly controls by ELISA.
Results.
We found significantly increased Ang-1 serum levels in patients with AD compared to control subjects (P=0.003).
There was no significant difference between MCI patients and healthy controls (P=0.553) or between AD and MCI patients (P=0.054).
The degree of cognitive impairment as measured by the mini-mental status examination (MMSE) score was significantly correlated with the Ang-1 serum levels in all patients and healthy controls.
Conclusions.
We found significantly increased Ang-1 serum levels in AD patients.
We could also show an association between Ang-1 serum levels and the cognitive status in all patients and healthy controls.
Thus, serum Ang-1 could be a potential candidate for a biomarker panel for AD diagnosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Schreitmüller, Brigitte& Leyhe, Thomas& Stransky, Elke& Köhler, Niklas& Laske, Christoph. 2012. Elevated Angiopoietin-1 Serum Levels in Patients with Alzheimer’s Disease. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-463491
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Schreitmüller, Brigitte…[et al.]. Elevated Angiopoietin-1 Serum Levels in Patients with Alzheimer’s Disease. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-463491
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Schreitmüller, Brigitte& Leyhe, Thomas& Stransky, Elke& Köhler, Niklas& Laske, Christoph. Elevated Angiopoietin-1 Serum Levels in Patients with Alzheimer’s Disease. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-463491
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463491
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)