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Effect of the African Traditional Medicine, Sutherlandia frutescens, on the Bioavailability of the Antiretroviral Protease Inhibitor, Atazanavir
المؤلفون المشاركون
Müller, Adrienne C.
Kanfer, Isadore
Skinner, Michael F.
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-12
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The objective of this study was to investigate the effect of Sutherlandia frutescens (SF) on the bioavailability of atazanavir (ATV) in twelve healthy male subjects.
During Phase I (Day 1), subjects ingested a single dose of ATV and blood samples were drawn before dose and at 0.5, 1.0, 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 5.0, 6.0, 9.0, 12, 18, and 24 hours after dose.
From Day 3 to Day 14, a single dose of milled SF was administered twice daily to each subject.
During Phase II, Day 15, subjects ingested single doses of ATV and SF.
Blood samples were drawn as previously described.
Plasma was harvested from blood samples and the concentration of ATV therein was determined.
For each phase, the mean ATV plasma concentration-time profile was plotted and the means of AUC0–24 and Cmax for ATV were computed.
The geometric mean ratios and confidence intervals (CIs) for Cmax and AUC0–24 hr were 0.783 (0.609–1.00) and 0.801 (0.634–1.01), respectively.
The CIs for both PK parameters fell below the limits of the “no-effect” boundary, set at 0.8–1.25, indicating that SF significantly reduced the bioavailability of ATV.
This may potentially result in subtherapeutic plasma concentrations and thus reduced anti-HIV efficacy of ATV.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Müller, Adrienne C.& Skinner, Michael F.& Kanfer, Isadore. 2013. Effect of the African Traditional Medicine, Sutherlandia frutescens, on the Bioavailability of the Antiretroviral Protease Inhibitor, Atazanavir. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-463549
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Müller, Adrienne C.…[et al.]. Effect of the African Traditional Medicine, Sutherlandia frutescens, on the Bioavailability of the Antiretroviral Protease Inhibitor, Atazanavir. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-463549
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Müller, Adrienne C.& Skinner, Michael F.& Kanfer, Isadore. Effect of the African Traditional Medicine, Sutherlandia frutescens, on the Bioavailability of the Antiretroviral Protease Inhibitor, Atazanavir. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-463549
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463549
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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