![](/images/graphics-bg.png)
Characteristic Analysis from Excessive to Deficient Syndromes in Hepatocarcinoma Underlying miRNA Array Data
المؤلفون المشاركون
Song, Ya-Nan
Zhang, Hui
Zhang, Gui-Biao
Su, Shi-Bing
Tang, Xin-sheng
Chen, Qi-long
Zhang, Wei
Zhou, Qian-mei
Lu, Yi-Yu
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-12-08
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Traditional Chinese medicine (TCM) treatment is regarded as a safe and effective method for many diseases.
In this study, the characteristics among excessive, excessive-deficient, and deficient syndromes of Hepatocellular carcinoma (HCC) were studied using miRNA array data.
We first calculated the differentially expressed miRNAs based on random module t-test and classified three TCM syndromes of HCC using SVM method.
Then, the weighted miRNA-target networks were constructed for different TCM syndromes using predicted miRNA targets.
Subsequently, the prioritized target genes of upexpression network of TCM syndromes were analyzed using DAVID online analysis.
The results showed that there are distinctly different hierarchical cluster and network structure of TCM syndromes in HCC, but the excessive-deficient combination syndrome is extrinsically close to deficient syndrome.
GO and pathway analysis revealed that the molecular mechanisms of excessive-deficient and deficient syndromes of HCC are more complex than excessive syndrome.
Furthermore, although excessive-deficient and deficient syndromes have similar complex mechanisms, excessive-deficient syndrome is more involved than deficient syndrome in development of cancer process.
This study suggested that miRNAs might be important mediators involved in the changing process from excessive to deficient syndromes and could be potential molecular markers for the diagnosis of TCM syndromes in HCC.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Qi-long& Lu, Yi-Yu& Zhang, Gui-Biao& Song, Ya-Nan& Zhou, Qian-mei& Zhang, Hui…[et al.]. 2013. Characteristic Analysis from Excessive to Deficient Syndromes in Hepatocarcinoma Underlying miRNA Array Data. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-463555
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Qi-long…[et al.]. Characteristic Analysis from Excessive to Deficient Syndromes in Hepatocarcinoma Underlying miRNA Array Data. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-463555
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Qi-long& Lu, Yi-Yu& Zhang, Gui-Biao& Song, Ya-Nan& Zhou, Qian-mei& Zhang, Hui…[et al.]. Characteristic Analysis from Excessive to Deficient Syndromes in Hepatocarcinoma Underlying miRNA Array Data. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-463555
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463555
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)