Patients with Poor Response to Antipsychotics Have a More Severe Pattern of Frontal Atrophy : A Voxel-Based Morphometry Study of Treatment Resistance in Schizophrenia
المؤلفون المشاركون
Casiello, Margherita
Palladino, Olga
Marsili, Angela
Salvatore, Marco
de Bartolomeis, Andrea
Quarantelli, Mario
Muscettola, Giovanni
Prinster, Anna
Brunetti, Arturo
Schiavone, Vittorio
Carotenuto, Barbara
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-23
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Approximately 30% of schizophrenia patients do not respond adequately to the therapy.
Previous MRI studies have suggested that drug treatment resistance is associated with brain morphological abnormalities, although region-of-interest analysis of MR studies from nonresponder and responder patients failed to demonstrate a statistically significant difference between these two schizophrenia subgroups.
We have used a voxel-based analysis of segmented MR studies to assess structural cerebral differences in 20 nonresponder and 15 responder patients and 16 age-matched normal volunteers.
Differences between the three groups emerged bilaterally mainly at the level of the superior and middle frontal gyri, primarily due to reduced grey matter volumes in nonresponders, as compared to both normal volunteers and responder patients.
Post hoc direct comparison between the two schizophrenia subgroups demonstrated significantly reduced grey matter volumes in middle frontal gyrus bilaterally, in the dorsolateral aspects of left superior frontal gyrus extending into postcentral gyrus and in the right medial temporal cortex.
Our results extend and integrate previous findings suggesting a more severe atrophy in nonresponder schizophrenia patients, compared to responder patients, mainly at the level of the superior and middle frontal gyri.
Longitudinal studies in drug-naïve patients are needed to assess the role of these associations.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Quarantelli, Mario& Palladino, Olga& Prinster, Anna& Schiavone, Vittorio& Carotenuto, Barbara& Brunetti, Arturo…[et al.]. 2014. Patients with Poor Response to Antipsychotics Have a More Severe Pattern of Frontal Atrophy : A Voxel-Based Morphometry Study of Treatment Resistance in Schizophrenia. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-463602
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Quarantelli, Mario…[et al.]. Patients with Poor Response to Antipsychotics Have a More Severe Pattern of Frontal Atrophy : A Voxel-Based Morphometry Study of Treatment Resistance in Schizophrenia. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-463602
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Quarantelli, Mario& Palladino, Olga& Prinster, Anna& Schiavone, Vittorio& Carotenuto, Barbara& Brunetti, Arturo…[et al.]. Patients with Poor Response to Antipsychotics Have a More Severe Pattern of Frontal Atrophy : A Voxel-Based Morphometry Study of Treatment Resistance in Schizophrenia. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-463602
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463602
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر