Muscle Relaxant and Sedative-Hypnotic Activities of Extract of Viola betonicifolia in Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin
المؤلفون المشاركون
Adhikari, Achyut
Saeed, Mohammad
Muhammad, Naveed
Khan, Khalid Mohammed
Khan, Haroon
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-09-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
The crude methanolic extract of the whole plant of Viola betonicifolia (VBME) was investigated for anxiolytic, muscle relaxant, sleep induction, antidepressant, and sedative activities) to ascertain its scientific values.
VBME showed a significant (P<0.05) dose dependent anxiolytic action in staircase test.
In muscle relaxant paradigms, a dose dependent muscle relaxation was observed.
For phenobarbitone sleep induction test, VBME notably (P<0.05) reduced the latency time and increased total sleeping duration.
Our tested extract was found free of any antidepressant activity, while the movement was significantly (P<0.05) shortened in locomotor activity.
The whole plant of V.
betonicifolia led to the isolation of 4-hydroxyl coumarin (4HC) which showed substantial safety profile in acute toxicity test.
When challenged in Traction and Chimney tests, it showed significant (P<0.05) muscle relaxant effect in both muscle relaxant paradigms at 20 and 30 mg/kg during various assessment times.
Nevertheless, 4HC was devoid of sedative and hypnotic potentials.
In conclusion, VBME had strong muscle relaxant and sedative-hypnotic properties, while its isolated compound, 4HC, possessed a significant muscle relaxant action with substantial safety profile without sedative-hypnotic effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Muhammad, Naveed& Saeed, Mohammad& Khan, Haroon& Adhikari, Achyut& Khan, Khalid Mohammed. 2013. Muscle Relaxant and Sedative-Hypnotic Activities of Extract of Viola betonicifolia in Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin. Journal of Chemistry،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-463719
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Muhammad, Naveed…[et al.]. Muscle Relaxant and Sedative-Hypnotic Activities of Extract of Viola betonicifolia in Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin. Journal of Chemistry No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-463719
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Muhammad, Naveed& Saeed, Mohammad& Khan, Haroon& Adhikari, Achyut& Khan, Khalid Mohammed. Muscle Relaxant and Sedative-Hypnotic Activities of Extract of Viola betonicifolia in Animal Models Supported by Its Isolated Compound, 4-Hydroxy Coumarin. Journal of Chemistry. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-463719
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463719
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر