Comparison of the Effects of Adenosine, Inosine, and Their Combination as an Adjunct to Reperfusion in the Treatment of Acute Myocardial Infarction
المؤلفون المشاركون
Shafy, Abdel
Chachques, Juan Carlos
Hupertan, Vincent
Lila, Nermine
Cortes-Morichetti, Miguel
Molinié, Vincent
المصدر
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-03-14
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Adenosine and inosine are both key intracellular energy substrates for nucleotide synthesis by salvage pathways, especially during ischemic stress conditions.
Additionally they both possess cell protective and cell repair properties.
The objective of this study is to detect potential advantages of the combination of adenosine and inosine versus each drug alone, in terms of ventricular function, infarct size reduction and angiogenesis.
Myocardial ischemia was created in rodents and treated with adenosine, inosine or their combination.
Results of experiments showed that the combination of both drugs significantly reduced infarct size and improved myocardial angiogenesis and ventricular function.
The two compounds, while chemically similar, use different intracellular pathways, allowing for complementary biological activities without overlapping.
The drug combination at specific 1 : 5 adenosine : inosine dose ratio demonstrated positive cardiologic effects, deserving further evaluation as an adjunct to reperfusion techniques during and after acute coronary syndrome.
The association of adenosine and inosine may contribute to reduce myocardial infarction morbidity and mortality rates.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shafy, Abdel& Molinié, Vincent& Cortes-Morichetti, Miguel& Hupertan, Vincent& Lila, Nermine& Chachques, Juan Carlos. 2012. Comparison of the Effects of Adenosine, Inosine, and Their Combination as an Adjunct to Reperfusion in the Treatment of Acute Myocardial Infarction. ISRN Cardiology،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shafy, Abdel…[et al.]. Comparison of the Effects of Adenosine, Inosine, and Their Combination as an Adjunct to Reperfusion in the Treatment of Acute Myocardial Infarction. ISRN Cardiology No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-463765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shafy, Abdel& Molinié, Vincent& Cortes-Morichetti, Miguel& Hupertan, Vincent& Lila, Nermine& Chachques, Juan Carlos. Comparison of the Effects of Adenosine, Inosine, and Their Combination as an Adjunct to Reperfusion in the Treatment of Acute Myocardial Infarction. ISRN Cardiology. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-463765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر