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Hair Analysis for Determination of Isoniazid Concentrations and Acetylator Phenotype during Antituberculous Treatment
المؤلفون المشاركون
Eisenhut, Michael
Sachs, Hans
Fieseler, Sybille
Schmid, Dagmar
Thieme, Detlef
المصدر
Tuberculosis Research and Treatment
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-10-02
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
Analysis of isoniazid (INH) uptake has been based on measurement of plasma concentrations providing a short-term and potentially biased view.
Objectives.
To establish hair analysis as a tool to measure long-term uptake of INH and to assess whether acetylator phenotype in hair reflects N-acetyltransferase-2 (NAT2) genotype.
Design and Methods.
INH and acetyl-INH concentrations in hair were determined in patients on INH treatment for M.
tuberculosis infection using high pressure liquid chromatography/mass spectrometry.
Acetyl-INH/INH ratios were correlated with NAT-2 genotype.
Results.
Hair concentrations of INH, determined in 40 patients, were not dependent on ethnic group or body mass index and were significantly higher in male compared to female patients (median (range) 2.37 ng/mg (0.76–4.9) versus 1.11 ng/mg (0.02–7.20) (P=0.02).
Acetyl-INH/INH ratios were a median of 15.2% (14.5 to 31.7) in homozygous rapid acetylator NAT-2 genotype and 37.3% (1.73 to 51.2) in the heterozygous rapid acetylator NAT-2 genotype and both significantly higher than in the slow acetylator NAT-2 genotype with 5.8% (0.53 to 14.4) (P<0.05).
Conclusions.
Results of hair analysis for INH showed lower concentrations in females.
Acetyl-INH/INH ratios were significantly lower in patients with slow acetylator versus rapid acetylator genotypes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Eisenhut, Michael& Thieme, Detlef& Schmid, Dagmar& Fieseler, Sybille& Sachs, Hans. 2012. Hair Analysis for Determination of Isoniazid Concentrations and Acetylator Phenotype during Antituberculous Treatment. Tuberculosis Research and Treatment،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-463782
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Eisenhut, Michael…[et al.]. Hair Analysis for Determination of Isoniazid Concentrations and Acetylator Phenotype during Antituberculous Treatment. Tuberculosis Research and Treatment No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-463782
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Eisenhut, Michael& Thieme, Detlef& Schmid, Dagmar& Fieseler, Sybille& Sachs, Hans. Hair Analysis for Determination of Isoniazid Concentrations and Acetylator Phenotype during Antituberculous Treatment. Tuberculosis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-463782
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463782
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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