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Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines
المؤلفون المشاركون
Serini, Simona
Cittadini, Achille
Trombino, Sonia
Mondella, Nadia
Lanza, Paola
Celleno, Leonardo
Fasano, Elena
Calviello, Gabriella
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-08-16
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Several advantages may derive from the use of dietary supplements containing multiple natural antioxidants and/or anti-inflammatory agents.
At present, however, there is scarce information on the properties and potential of combined supplements.
To fill the gap, the antioxidant and anti-inflammatory activities exerted by a combination of seven natural components (coenzyme Q10, krill oil, lipoic acid, resveratrol, grape seed oil, α-tocopherol, and selenium) contained in a dietary supplement used for the prevention of skin disorders were investigated in vitro.
Each component was administered, alone or in combination, to human keratinocytes, and the inhibition of Reactive Oxygen Species production and lipid peroxidation as well as the ability to reduce inflammatory cytokine secretion and to modulate Nuclear Factor-κB pathway was evaluated.
The combination exhibited high antioxidant activity and in specific conditions the combination’s efficiency was higher than that of the most powerful components administered individually.
Moreover, the combination showed remarkable anti-inflammatory properties.
It reduced more efficiently than each component the secretion of Monocyte Chemoattractant Protein-1, a crucial cytokine for the development of chronic inflammation in skin, and inhibited Nuclear Factor-κB molecular pathway.
Overall, our findings suggest that the combined formulation may have the potential to powerfully inhibit oxidative stress and inflammation at skin level.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fasano, Elena& Serini, Simona& Mondella, Nadia& Trombino, Sonia& Celleno, Leonardo& Lanza, Paola…[et al.]. 2014. Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-463841
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fasano, Elena…[et al.]. Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-463841
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fasano, Elena& Serini, Simona& Mondella, Nadia& Trombino, Sonia& Celleno, Leonardo& Lanza, Paola…[et al.]. Antioxidant and Anti-Inflammatory Effects of Selected Natural Compounds Contained in a Dietary Supplement on Two Human Immortalized Keratinocyte Lines. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-463841
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463841
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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