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The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes
المؤلفون المشاركون
Zhou, Hong-Hao
Li, Xi
Lian, Feng-Mei
Zhou, Qiang
Zhang, Wei
Deng, Sheng
Peng, Jing-Bo
Fan, Lan
Qu, Ke-Yi
Zhu, Yan
Chen, Xin-Yan
Tang, Jie
Tong, Xiao-Lin
Zhong, Qi
Deng, Hong-Wen
Xiao, Xin-Hua
Bai, Yu-Jing
Guo, Dong
Sha, Yi-Ling
Wang, Yan-Rong
Liu, Zhao-Qian
المصدر
Evidence-Based Complementary and Alternative Medicine
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-04-29
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Therapeutic interventions in prediabetes are important in the primary prevention of type 2 diabetes (T2D) and its chronic complications.
However, little is known about the pharmacogenetic effect of traditional herbs on prediabetes treatment.
A total of 194 impaired glucose tolerance (IGT) subjects were treated with traditional hypoglycemic herbs (Tianqi Jiangtang) for 12 months in this study.
DNA samples were genotyped for 184 mutations in 34 genes involved in drug metabolism or transportation.
Multinomial logistic regression analysis indicated that rs1142345 (A>G) in the thiopurine S-methyltransferase (TPMT) gene was significantly associated with the hypoglycemic effect of the drug (P=0.001, FDR P=0.043).
The “G” allele frequencies of rs1142345 in the healthy (subjects reverted from IGT to normal glucose tolerance), maintenance (subjects still had IGT), and deterioration (subjects progressed from IGT to T2D) groups were 0.094, 0.214, and 0.542, respectively.
Binary logistic regression analysis indicated that rs1142345 was also significantly associated with the hypoglycemic effect of the drug between the healthy and maintenance groups (P=0.027, OR=4.828) and between the healthy and deterioration groups (P=0.001, OR=7.811).
Therefore, rs1142345 was associated with the clinical effect of traditional hypoglycemic herbs.
Results also suggested that TPMT was probably involved in the pharmacological mechanisms of T2D.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Xi& Lian, Feng-Mei& Guo, Dong& Fan, Lan& Tang, Jie& Peng, Jing-Bo…[et al.]. 2013. The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-463861
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Xi…[et al.]. The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-463861
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Xi& Lian, Feng-Mei& Guo, Dong& Fan, Lan& Tang, Jie& Peng, Jing-Bo…[et al.]. The rs1142345 in TPMT Affects the Therapeutic Effect of Traditional Hypoglycemic Herbs in Prediabetes. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-463861
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463861
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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