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Amyloid Beta Peptides Differentially Affect Hippocampal Theta Rhythms In Vitro
المؤلفون المشاركون
Peña-Ortega, Fernando
Gutiérrez-Lerma, Armando I.
Ordaz, Benito
المصدر
International Journal of Peptides
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-06-25
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Soluble amyloid beta peptide (Aβ) is responsible for the early cognitive dysfunction observed in Alzheimer's disease.
Both cholinergically and glutamatergically induced hippocampal theta rhythms are related to learning and memory, spatial navigation, and spatial memory.
However, these two types of theta rhythms are not identical; they are associated with different behaviors and can be differentially modulated by diverse experimental conditions.
Therefore, in this study, we aimed to investigate whether or not application of soluble Aβ alters the two types of theta frequency oscillatory network activity generated in rat hippocampal slices by application of the cholinergic and glutamatergic agonists carbachol or DHPG, respectively.
Due to previous evidence that oscillatory activity can be differentially affected by different Aβ peptides, we also compared Aβ25−35 and Aβ1−42 for their effects on theta rhythms in vitro at similar concentrations (0.5 to 1.0 μM).
We found that Aβ25−35 reduces, with less potency than Aβ1−42, carbachol-induced population theta oscillatory activity.
In contrast, DHPG-induced oscillatory activity was not affected by a high concentration of Aβ25−35 but was reduced by Aβ1−42.
Our results support the idea that different amyloid peptides might alter specific cellular mechanisms related to the generation of specific neuronal network activities, instead of exerting a generalized inhibitory effect on neuronal network function.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gutiérrez-Lerma, Armando I.& Ordaz, Benito& Peña-Ortega, Fernando. 2013. Amyloid Beta Peptides Differentially Affect Hippocampal Theta Rhythms In Vitro. International Journal of Peptides،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-463899
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gutiérrez-Lerma, Armando I.…[et al.]. Amyloid Beta Peptides Differentially Affect Hippocampal Theta Rhythms In Vitro. International Journal of Peptides No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-463899
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gutiérrez-Lerma, Armando I.& Ordaz, Benito& Peña-Ortega, Fernando. Amyloid Beta Peptides Differentially Affect Hippocampal Theta Rhythms In Vitro. International Journal of Peptides. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-463899
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463899
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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