Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy : Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism
المؤلفون المشاركون
D'Agostino, G.
Ghelardini, Carla
Pacini, A.
Zanardelli, Matteo
Calignano, A.
Russo, R.
Di Cesare Mannelli, Lorenzo
المصدر
العدد
المجلد 2013، العدد 2013 (31 ديسمبر/كانون الأول 2013)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2013-02-25
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Neuropathic syndromes which are evoked by lesions to the peripheral or central nervous system are extremely difficult to treat, and available drugs rarely joint an antihyperalgesic with a neurorestorative effect.
N-Palmitoylethanolamine (PEA) exerts antinociceptive effects in several animal models and inhibits peripheral inflammation in rodents.
Aimed to evaluate the antineuropathic properties of PEA, a damage of the sciatic nerve was induced in mice by chronic constriction injury (CCI) and a subcutaneous daily treatment with 30 mg kg−1 PEA was performed.
On the day 14, PEA prevented pain threshold alterations.
Histological studies highlighted that CCI induced oedema and an important infiltrate of CD86 positive cells in the sciatic nerve.
Moreover, osmicated preparations revealed a decrease in axon diameter and myelin thickness.
Repeated treatments with PEA reduced the presence of oedema and macrophage infiltrate, and a significant higher myelin sheath, axonal diameter, and a number of fibers were observable.
In PPAR-α null mice PEA treatment failed to induce pain relief as well as to rescue the peripheral nerve from inflammation and structural derangement.
These results strongly suggest that PEA, via a PPAR-α-mediated mechanism, can directly intervene in the nervous tissue alterations responsible for pain, starting to prevent macrophage infiltration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Di Cesare Mannelli, Lorenzo& D'Agostino, G.& Pacini, A.& Russo, R.& Zanardelli, Matteo& Ghelardini, Carla…[et al.]. 2013. Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy : Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-463957
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Di Cesare Mannelli, Lorenzo…[et al.]. Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy : Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism. Mediators of Inflammation No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-463957
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Di Cesare Mannelli, Lorenzo& D'Agostino, G.& Pacini, A.& Russo, R.& Zanardelli, Matteo& Ghelardini, Carla…[et al.]. Palmitoylethanolamide Is a Disease-Modifying Agent in Peripheral Neuropathy : Pain Relief and Neuroprotection Share a PPAR-Alpha-Mediated Mechanism. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-463957
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463957
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر