miRNA Transcriptome of Hypertrophic Skeletal Muscle with Overexpressed Myostatin Propeptide
المؤلفون المشاركون
Javed, Ruheena
Jing, Lu
Cao, Jianhua
Li, Xinyun
Zhao, Shuhong
Yang, Jinzeng
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-07-24
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
MicroRNAs (miRNAs) play an imperative role in cell proliferation, differentiation, and cell metabolism through regulation of gene expression.
Skeletal muscle hypertrophy that results from myostatin depression by its propeptide provides an interesting model to understand how miRNA transcriptome is involved in myostatin-based fiber hypertrophy.
This study employed Solexa deep sequencing followed by Q-PCR methods to analyze miRNA transcriptome of skeletal muscle of myostatin propeptide transgenic mice in comparison with their littermate controls.
A total of 461 mature known and 69 novel miRNAs were reported from this study.
Fifty-seven miRNAs were expressed differentially between transgenic and littermate controls, of which most abundant miRNAs, miR-133a and 378a, were significantly differentially expressed.
Expression profiling was validated on 8 known and 2 novel miRNAs.
The miRNA targets prediction and pathway analysis showed that FST, SMAD3, TGFBR1, and AcvR1a genes play a vital role in skeletal muscle hypertrophy in the myostatin propeptide transgenic mice.
It is predicted that miR-101 targeted to TGFBR1 and SMAD3, miR-425 to TGFBR2 and FST, and miR-199a to AcvR2a and TGF-β genes.
In conclusion, the study offers initial miRNA profiling and methodology of miRNA targets prediction for myostatin-based hypertrophy.
These differentially expressed miRNAs are proposed as candidate miRNAs for skeletal muscle hypertrophy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Javed, Ruheena& Jing, Lu& Yang, Jinzeng& Li, Xinyun& Cao, Jianhua& Zhao, Shuhong. 2014. miRNA Transcriptome of Hypertrophic Skeletal Muscle with Overexpressed Myostatin Propeptide. BioMed Research International،Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-463962
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Javed, Ruheena…[et al.]. miRNA Transcriptome of Hypertrophic Skeletal Muscle with Overexpressed Myostatin Propeptide. BioMed Research International No. 2014 (2014), pp.1-19.
https://search.emarefa.net/detail/BIM-463962
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Javed, Ruheena& Jing, Lu& Yang, Jinzeng& Li, Xinyun& Cao, Jianhua& Zhao, Shuhong. miRNA Transcriptome of Hypertrophic Skeletal Muscle with Overexpressed Myostatin Propeptide. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-19.
https://search.emarefa.net/detail/BIM-463962
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-463962
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر