Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor
المؤلفون المشاركون
Mansour, Mahmoud A.
al-Shebly, Mashael M.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2012-07-24
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
العلوم الطبيعية والحياتية (متداخلة التخصصات)
الأحياء
الملخص EN
Pregnancy in insulin-dependent diabetes mellitus is associated with a greater incidence of fetal abnormality.
Animal studies suggested that increased free-radical production and antioxidant depletion may contribute to this risk.
The objective of this work was to evaluate oxidative stress and antioxidant capacity in hypertensive, diabetics, and healthy control women during labor.
Simultaneous determination of antioxidant enzymes activities, namely glutathione peroxidase (GSH-Px), glutathione reductase (GSH-red), superoxide dismutase (SOD), total antioxidant, and lipid peroxides measured as thiobarbituric acid-reactive substances (TBARS) levels, were carried out in maternal plasma during labor.
Plasma GSH-Px activity was found to be significantly increased as it doubled in hypertensive, and diabetic women when compared with healthy control women (P<0.05).
In contrast, plasma SOD activity was significantly decreased in both groups when compared to the control group (P<0.05).
No significant differences were detected in GSH-Red activity between diabetic, hypertensive and control groups.
Alterations in antioxidant enzyme activities were accompanied by a significant increase in the levels of plasma lipid peroxides in hypertensive and diabetic women during labor.
Plasma levels of total antioxidants were significantly increased in diabetic women as compared with the control group.
Based on our results, it may be concluded that enhanced generation of oxidative stress causes alteration of antioxidant capacity in diabetic and hypertensive women during labor.
Alterations in antioxidant and prooxidant components may result in various complications including peroxidation of vital body molecules which may be regarded as an increased risk factor for pregnant women as well as the fetus.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
al-Shebly, Mashael M.& Mansour, Mahmoud A.. 2012. Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor. Oxidative Medicine and Cellular Longevity،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-464069
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
al-Shebly, Mashael M.& Mansour, Mahmoud A.. Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor. Oxidative Medicine and Cellular Longevity No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-464069
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
al-Shebly, Mashael M.& Mansour, Mahmoud A.. Evaluation of Oxidative Stress and Antioxidant Status in Diabetic and Hypertensive Women during Labor. Oxidative Medicine and Cellular Longevity. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-464069
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464069
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر