Thr92Ala Polymorphism of Human Type 2 Deiodinase Gene (hD2)‎ Affects the Development of Graves' Disease, Treatment Efficiency, and Rate of Remission

المؤلفون المشاركون

Olga, Freylihman
Anna, Kostareva
Babenko, A. Y.
Vladislav, Solncev
Daria, Popkova
Elena, Grineva

المصدر

Clinical and Developmental Immunology

العدد

المجلد 2012، العدد 2012 (31 ديسمبر/كانون الأول 2012)، ص ص. 1-5، 5ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2012-11-12

دولة النشر

مصر

عدد الصفحات

5

التخصصات الرئيسية

الأحياء

الملخص EN

Clinical symptoms vary in thyrotoxicosis, and severity of these depends on many factors.

Over the last years, impact of genetic factors upon the development and clinical significance of thyrotoxic symptoms became evident.

It is known that a production of T3 in various tissues is limited by deiodinase 2 (D2).

Recent studies revealed that certain single nucleotide polymorphisms (including threonine (Thr) to alanine (Ala) replacement in D2 gene codon 92, D2 Thr92Ala) affect T3 levels in tissues and in serum.

Individuals with Ala92Ala genotype have lower D2 activity in tissues, compared with that in individuals with other genotypes.

In our study, we have assessed an association of D2 Thr92Ala polymorphism with (1) frequency of disease development, (2) severity of clinical symptoms of thyrotoxicosis, and (3) rate of remissions, in Graves' disease patients.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Babenko, A. Y.& Daria, Popkova& Olga, Freylihman& Vladislav, Solncev& Anna, Kostareva& Elena, Grineva. 2012. Thr92Ala Polymorphism of Human Type 2 Deiodinase Gene (hD2) Affects the Development of Graves' Disease, Treatment Efficiency, and Rate of Remission. Clinical and Developmental Immunology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-464141

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Babenko, A. Y.…[et al.]. Thr92Ala Polymorphism of Human Type 2 Deiodinase Gene (hD2) Affects the Development of Graves' Disease, Treatment Efficiency, and Rate of Remission. Clinical and Developmental Immunology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-464141

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Babenko, A. Y.& Daria, Popkova& Olga, Freylihman& Vladislav, Solncev& Anna, Kostareva& Elena, Grineva. Thr92Ala Polymorphism of Human Type 2 Deiodinase Gene (hD2) Affects the Development of Graves' Disease, Treatment Efficiency, and Rate of Remission. Clinical and Developmental Immunology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-464141

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-464141