Neuroantibody Biomarkers : Links and Challenges in Environmental Neurodegeneration and Autoimmunity
المؤلف
المصدر
العدد
المجلد 2014، العدد 2014 (31 ديسمبر/كانون الأول 2014)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2014-06-22
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The majority of neurodegenerative (ND) and autoimmune diseases (AID) remain idiopathic.
The contribution of environmental chemicals to the development of these disorders has become of great interest in recent years.
A convergence of mechanism between of ND and AID development has also emerged.
In the case of ND, including neurotoxicity, the focus of this review, work over the last two decade in the realm of biomarker development, indicates that the immune response provides a venue whereby humoral immunity, in the form of autoantibodies to nervous system specific proteins, or neuroantibodies (NAb), may provide, once validated, a sensitive high throughput surrogate biomarker of effect with the potential of predicting outcome in absence of overt neurotoxicity/neurodegeneration.
In addition, NAb may prove to be a contributor to the progression of the nervous system pathology, as well as biomarker of stage and therapeutic efficacy.
There is a compelling need for biomarkers of effect in light of the introduction of new chemicals, such as nanoengineered material, where potential neurotoxicity remains to be defined.
Furthermore, the convergence of mechanisms associated with ND and AID draws attention to the neglected arena of angiogenesis in defining the link between environment, ND, and AID.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
El-Fawal, Hassan A. N.. 2014. Neuroantibody Biomarkers : Links and Challenges in Environmental Neurodegeneration and Autoimmunity. Autoimmune Diseases،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-464187
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
El-Fawal, Hassan A. N.. Neuroantibody Biomarkers : Links and Challenges in Environmental Neurodegeneration and Autoimmunity. Autoimmune Diseases No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-464187
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
El-Fawal, Hassan A. N.. Neuroantibody Biomarkers : Links and Challenges in Environmental Neurodegeneration and Autoimmunity. Autoimmune Diseases. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-464187
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-464187
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر